N-Amino-chinolinium | 45874-38-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-Amino-chinolinium
• 英文别名: quinolin-1-ium-1-amine
• CAS: 45874-38-2
• 化学式: C₉H₉N₂
• 分子量: 145.184
• InChiKey: XNJRVIPOYDUAMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-Amino-chinolinium 在 重水 作用下， 生成 2-Deuterioquinolin-1-ium-1-amine
  参考文献：
  名称：

  Wu, Wei; Saeki, Ken-Ichi; Terashima, Isamu, Heterocycles, 1996, vol. 43, # 9, p. 1951 - 1958

  摘要：

  DOI：

文献信息

• [3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor
  作者：Alexander V. Aksenov、Nikolai A. Arutiunov、Nikita K. Kirilov、Dmitrii A. Aksenov、Igor Yu. Grishin、Nicolai A. Aksenov、Huifen Wang、Liqin Du、Tania Betancourt、Stephen C. Pelly、Alexander Kornienko、Michael Rubin

  DOI：10.1039/d1ob01141c

  日期：——

  via [3 + 2]-cycloaddition of pyridinium ylides to 1-chloro-2-nitrostyrenes. The synthesized molecules were evaluated for antiproliferative activities against a BE(2)-C neuroblastoma cell line with several compounds decreasing the viability of cancer cells. Indolizine 9db showed higher potency than that of all-trans-retinoic acid, an approved cancer drug. Mechanistically, it was found to inhibit tubulin

  中氮茚和吡唑并[1,5- a ]吡啶是通过吡啶鎓叶立德与1-氯-2-硝基苯乙烯的[3+2]-环加成反应制备的。评估了合成分子对 BE(2)-C 神经母细胞瘤细胞系的抗增殖活性，其中几种化合物可降低癌细胞的活力。中氮茚9db显示出比全反式视黄酸（一种已批准的抗癌药物）更高的效力。从机制上讲，它被发现可以抑制微管蛋白聚合，因此提出可以利用所发现的化学物质来开发新型微管靶向抗癌剂。
• [EN] AMINOQUINOLINIUM SALTS, METHODS OF THEIR PRODUCTION AND THEIR USE AS ACTIVE AGENTS FOR BIOTECHNOLOGICAL AND MEDICAL APPLICATIONS AGAINST BINARY TOXINS<br/>[FR] SELS D'AMINOQUINOLINE, LEURS PROCÉDÉS DE PRODUCTION ET LEUR UTILISATION EN TANT QU'AGENTS ACTIFS POUR DES APPLICATIONS BIOTECHNOLOGIQUES ET MÉDICALES CONTRE LES TOXINES BINAIRES
  申请人：UNIV WUERZBURG J MAXIMILIANS

  公开号：WO2012041493A1

  公开（公告）日：2012-04-05

  The present invention relates to aminoquinoline salts, their uses and to methods of synthesizing such aminoquinoline salts. Moreover, the present invention relates to compositions comprising aminoquinoline salts in accordance with the present invention. The present invention relates to bioactive compounds from the class of aminoquinoline compounds, and in particular their inhibitory effects on the binary toxins of an AB-type of a number of bacteria, such as Clostridium perfringens, Clostridium botulinum, and Bacillus anthracis. The invention also relates to the use of these aminoquinoline compounds as drugs, more particularly as drugs for the treatment of bacterial infections, even more particularly bacterial infections caused by bacteria which produce pore forming toxins of a binary type. The present invention also relates to methods of producing the compounds in accordance with the present invention.

  本发明涉及氨基喹啉盐，其用途以及合成此类氨基喹啉盐的方法。此外，本发明涉及包含根据本发明的氨基喹啉盐的组合物。本发明涉及来自氨基喹啉化合物类的生物活性化合物，特别是它们对多种细菌的AB型二元毒素的抑制作用，如厌氧梭菌、肉毒梭菌和炭疽芽孢杆菌。该发明还涉及将这些氨基喹啉化合物用作药物，更具体地用作治疗细菌感染的药物，尤其是由产生二元型毒素的细菌引起的细菌感染。本发明还涉及根据本发明生产这些化合物的方法。
• [EN] CATIONIC DIRECT DYE COMPRISING AN ALIPHATIC CHAIN AND BEARING A DISULFIDE/THIOL/PROTECTED-THIOL FUNCTION FOR DYEING KERATIN FIBRES<br/>[FR] COLORANT DIRECT CATIONIQUE COMPRENANT UNE CHAÎNE ALIPHATIQUE ET PORTANT UNE FONCTION DE DISULFURE/THIOL/THIOL PROTÉGÉ POUR COLORER DES FIBRES DE KÉRATINE
  申请人：OREAL

  公开号：WO2017081314A1

  公开（公告）日：2017-05-18

  A subject of the invention is a process for dyeing keratin fibres such as the hair, using at least one cationic direct dye bearing a disulfide, thiol or protected-thiol function and comprising at least one ammonium group bearing an aliphatic chain (I). Another subject of the invention is the use i) of at least one cationic direct dye bearing a disulfide, thiol or protected-thiol function (I) combined with ii) steam and/or a heating iron for straightening keratin fibres, for dyeing keratin fibres, and novel cationic direct dyes bearing a disulfide, thiol or protected-thiol function (I), and also a cosmetic composition comprising same. The process used and the use of the thiol, protected-thiol or disulfide dyes combined with steam makes it possible in particular to obtain a long-lasting colouration with a care valency on the keratin fibres.

  本发明涉及一种用于染色角蛋白纤维（如头发）的方法，该方法使用至少一种带有二硫化物、巯基或受保护巯基功能的阳离子直接染料，并包括至少一种带有脂肪链的铵基（I）。本发明的另一个方面是使用i）至少一种带有二硫化物、巯基或受保护巯基功能的阳离子直接染料（I）结合ii）蒸汽和/或加热熨斗来拉直角蛋白纤维，用于染色角蛋白纤维，并且还包括带有相同成分的新型带有二硫化物、巯基或受保护巯基功能（I）的阳离子直接染料，以及一种化妆品组合物。使用巯基、受保护巯基或二硫化物染料结合蒸汽的方法，特别可以获得具有对角蛋白纤维的护理价值的持久着色效果。
• Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents
  申请人：Sanchez Muriel

  公开号：US20070060558A1

  公开（公告）日：2007-03-15

  The invention concerns an aminoquinoline-antibiotic hybrid compound of general formula (I): Q—(Y 1 ) p —(U) p —(Y 2 ) p -A: wherein Q represents an aminoquinoline, (Y 1 ) p (U) p —(Y 2 ) p″ is an optional spacer and A is an antibiotic residue. The invention enables the antibiotic residue activity to be unexpectedly enhanced.

  本发明涉及一种氨基喹啉-抗生素杂合物，其一般式为(I)：Q—(Y1)p—(U)p—(Y2)p-A，其中Q代表氨基喹啉，(Y1)p(U)p—(Y2)p″是可选的间隔基，A为抗生素残基。本发明使得抗生素残基的活性得到了意外的增强。
• CATIONIC DIRECT DYE COMPRISING AN ALIPHATIC CHAIN AND BEARING A DISULFIDE/THIOL/PROTECTED-THIOL FUNCTION FOR DYEING KERATIN FIBRES
  申请人：L'Oréal

  公开号：EP3373902B1

  公开（公告）日：2020-04-29