1-Methoxy-4-methylpent-2-yne | 1352638-36-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Methoxy-4-methylpent-2-yne
• CAS: 1352638-36-8
• 化学式: C₇H₁₂O
• 分子量: 112.172
• InChiKey: OLRLOQXHJLYNSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Benzophenon-(O-benzyl-oxim) 、 1-Methoxy-4-methylpent-2-yne 在 1,1'-双(二苯基膦)二茂铁 、 bis(1,5-cyclooctadiene)nickel (0) 作用下， 以 甲苯 为溶剂， 生成 3-isopropyl-4-(methoxymethyl)-1-phenylisoquinoline 、 4-isopropyl-3-(methoxymethyl)-1-phenylisoquinoline
  参考文献：
  名称：

  Nickel-catalyzed Cycloaddition of Aromatic (O-Benzyl)ketoximes with Alkynes to Produce Isoquinoline and IsoquinolineN-Oxide Derivatives

  摘要：

  研究人员开发了一种镍催化的芳香族（O-苄基）酮肟与炔烃的环加成反应，从而制备出 3,4-二取代的异喹啉衍生物。该反应涉及 O-苄基酮肟的 N-O 键与 Ni(0) 的氧化加成，以及随后通过消除苄醇激活分子间的 C-H 键。研究还发现，酮肟参与了镍催化的炔烃反应，生成异喹啉 N-氧化物衍生物。

  DOI：

  10.1246/cl.2011.1140

文献信息

• FUNGICIDES
  申请人：Murphy Kessabi Fiona

  公开号：US20100056570A1

  公开（公告）日：2010-03-04

  Compounds of the general formula wherein the substituents are as defined in claim ( 1 ), are useful as fungicides.

  通式为（公式），其中取代基如权利要求（1）所定义的化合物，可用作杀真菌剂。
• 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
  申请人：Chau Anh

  公开号：US20090075998A1

  公开（公告）日：2009-03-19

  The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

  该发明涵盖了式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗多种疾病或情况引起的疼痛和/或炎症，如骨关节炎，类风湿性关节炎和急性或慢性疼痛。还包括治疗由mPGES-1酶介导的疾病或情况的方法和制药组合物。
• 2-(Phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
  申请人：Chau Anh

  公开号：US20070208017A1

  公开（公告）日：2007-09-06

  The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

  本发明涵盖了公式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合成酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病况引起的疼痛和/或炎症，如骨关节炎、类风湿性关节炎和急性或慢性疼痛。还包括治疗由mPGES-1酶介导的疾病或病况的方法和制药组合物。
• 2-(Phenyl or Heterocyclic)-1H-Phenanthro[9,10-D]Imidazoles
  申请人：Chau Anh

  公开号：US20090286772A1

  公开（公告）日：2009-11-19

  The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

  该发明涵盖了公式（I）的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合成酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或情况引起的疼痛和/或炎症，例如骨关节炎，类风湿性关节炎和急性或慢性疼痛。还包括治疗由mPGES-1酶介导的疾病或情况的方法和制药组合物。
• Aminopropenoates as Fungicides
  申请人：DUBOST Christophe

  公开号：US20110152322A1

  公开（公告）日：2011-06-23

  The present invention relates to aminopropenoate derivatives, the process of their preparation, intermediate compounds, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants and in material protection, using these compounds or compositions.

  本发明涉及氨基丙烯酸酯衍生物，其制备过程，中间化合物，它们作为杀真菌活性剂的用途，特别是作为杀真菌组合物的形式，以及使用这些化合物或组合物控制植物病原真菌，尤其是在材料保护方面的方法。