4-hydroxy-6-[2-(8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl)ethyl]-tetrahydro-pyran-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 4-hydroxy-6-[2-(8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl)ethyl]-tetrahydro-pyran-2-one
• 英文别名: 4-Hydroxy-6-[2-(8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl]oxan-2-one
• 化学式: C₁₉H₂₈O₄
• 分子量: 320.429
• InChiKey: ZDFOBOYQVYMVCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-hydroxy-6-[2-(8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl)ethyl]-tetrahydro-pyran-2-one 、 二氯二甲基硅烷 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  [EN] PROCESS FOR PREPARING SIMVASTATIN.
  [FR] PROCEDE DE PREPARATION DE SIMVASTATINE

  摘要：

  本发明涉及一种制备辛伐他汀的方法，包括以下步骤：将式4的二元醇内酯与二取代硅烷二氯化物（二氯硅烷）反应，得到式5的二元醇内酯二聚体，然后用2,2-二甲基丁酰氯酰化二元醇内酯二聚体，得到式6的辛伐他汀二聚体，最后去保护辛伐他汀二聚体，得到辛伐他汀。该方法制造步骤简单，使用的保护剂价格便宜，具有出色的生产效率和经济效益。

  公开号：

  WO2005058861A1
• 作为产物：
  描述：

  7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid 以 甲苯 为溶剂， 反应 1.0h， 以95%的产率得到4-hydroxy-6-[2-(8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl)ethyl]-tetrahydro-pyran-2-one
  参考文献：
  名称：

  [EN] PROCESS FOR PREPARING SIMVASTATIN.
  [FR] PROCEDE DE PREPARATION DE SIMVASTATINE

  摘要：

  本发明涉及一种制备辛伐他汀的方法，包括以下步骤：将式4的二元醇内酯与二取代硅烷二氯化物（二氯硅烷）反应，得到式5的二元醇内酯二聚体，然后用2,2-二甲基丁酰氯酰化二元醇内酯二聚体，得到式6的辛伐他汀二聚体，最后去保护辛伐他汀二聚体，得到辛伐他汀。该方法制造步骤简单，使用的保护剂价格便宜，具有出色的生产效率和经济效益。

  公开号：

  WO2005058861A1

文献信息

• HYPOCHOLESTEROLEMIC, ANTI-INFLAMMATORY AND ANTIEPILEPTIC NEUROPROTECTIVE COMPOUND
  申请人：Burgos Muñoz Javier Santos

  公开号：US20130197073A1

  公开（公告）日：2013-08-01

  The present invention describes a compound of formula (I) its hydroxy acid form, the pharmaceutically acceptable salts of said hydroxy acid and pharmaceutically acceptable prodrugs and solvates of the compound and of its hydroxy acid form and, in particular, said compound, its hydroxy acid form, salts, etc. for use in the prevention of: neurodegenerative diseases, cognitive impairment, diseases associated with undesired oxidation, age-associated pathological processes and progeria, cardiovascular diseases such as atherosclerosis, atrial fibrillation, dyslipidemia, hypercholesterolemia, hyperlipidemia, and hypertriglyceridemia, inflammation or inflammatory processes, or epilepsy, epileptic seizures and convulsions.

  本发明描述了式(I)的化合物，其羟基酸形式，所述羟基酸的药学上可接受的盐，以及所述化合物及其羟基酸形式的药学上可接受的前药和溶剂化物，特别是所述化合物、其羟基酸形式、盐等用于预防：神经退行性疾病、认知障碍、与不良氧化相关的疾病、年龄相关的病理过程和早衰、心血管疾病，如动脉粥样硬化、心房颤动、血脂异常、高胆固醇血症、高脂血症和高甘油三酯血症、炎症或炎症过程，或癫痫、癫痫发作和惊厥。
• PROCEDE D'ACYLATION ENZYMATIQUE AVEC UN DONNEUR ACYL-PHOSPHONATE
  申请人：PCAS Biosolution

  公开号：EP2598644A1

  公开（公告）日：2013-06-05
• Enzymatic Acylation Method Using an Acylphosphonate Donor
  申请人：Martin Juliette

  公开号：US20130130337A1

  公开（公告）日：2013-05-23

  The invention relates to an enzymatic acylation method including at least the following steps of: contacting at least one compound having at least one function selected from among the amine, alcohol, or thiol functions, at least one microorganism having an acyl transfer activity and/or an acyl transfer enzyme, and at least one acylphosphonate donor of formula (I), where: R is an alkyl, alkene, uikyne, aryl, or aralkyl radical, or is —ORa, —SRa, —NRaRb, where Ra and Rb are identical or different and are H, an alkyl, alkene, alkyne, aryl or aralkyl radical, the alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; X is O or S; Y and Z, which are identical or different, are —OR1, —OR2, —SR1, —SR2, —NR′1R″1, —NR′2R″2; R1, R2, R′1, R′2, R″1 and R″2, which are identical or different, are an alkyl, alkene, alkyne, aryl or aralkyl radical, said alkyl, alkene, alkyne, aryl or aralkyl radicals being optionally substituted; and recovering the compound including at least one acyl function, said function being selected from among the amine, alcohol, or thiol functions.
• ANTIEPILEPTIC, HYPOCHOLESTEROLEMIC AND NEUROPROTECTIVE COMPOUND
  申请人：NEURON BIOPHARMA, S.A.

  公开号：US20140309295A1

  公开（公告）日：2014-10-16

  The present invention describes a compound of formula (I) its hydroxy acid form, the pharmaceutically acceptable salts of said hydroxy acid and pharmaceutically acceptable prodrugs and solvates of the compound and of its hydroxy acid form and, in particular, said compound, its hydroxy acid form, salts, etc. for its use in the prevention of: neurodegenerative diseases, cognitive deterioration, diseases associated with undesired oxidation, age-associated pathological processes and progeria, epilepsy, epileptic seizures and convulsions, cardiovascular diseases such as atherosclerosis, atrial fibrillation, dyslipemia, hypercholesterolemia, hyperlipidemia, and hypertriglyceridemia, or fungal or viral infections.
• US9145570B2
  申请人：——

  公开号：US9145570B2

  公开（公告）日：2015-09-29