1-azido-2-(4-methyl-3-phenyl-penta-1,2,4-trienyl)-benzene | 1020202-70-3

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 1-azido-2-(4-methyl-3-phenyl-penta-1,2,4-trienyl)-benzene
• CAS: 1020202-70-3
• 化学式: C₁₈H₁₅N₃
• 分子量: 273.337
• InChiKey: HROOQZSOGKNBTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  14.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-azido-2-(4-methyl-3-phenyl-penta-1,2,4-trienyl)-benzene 在 copper(l) iodide 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以69%的产率得到2-methyl-3-phenyl-1,4-dihydro-cyclopenta[b]indole
  参考文献：
  名称：

  Allenyl Azide Cycloaddition Chemistry. 2,3-Cyclopentennelated Indole Synthesis through Indolidene Intermediates

  摘要：

  The thermal, photochemical, and photochemical/CuI-mediated cascade cyclizations of a range of substituted 1-(2-azidophenyl)-3-alkenylallenes are described. These reactions provide both 1,2- and 2,3-cyclopentennelated indole products in varying ratios. In most cases, high regioselectivity for the 2,3-annelated isomer can be achieved under the hv/CuI conditions. Computational studies of this multistep reaction support the intermediacy of indolidene intermediates whose electrocyclizations (with or without copper present) define the regioselectivity branch point in the sequence.

  DOI：

  10.1021/jo900659w
• 作为产物：
  描述：

  1-((2-azidophenyl)-3-phenylprop-2-yn-1-yl) acetate 、 异丙烯基溴化镁 在 zinc(II) chloride 、 四(三苯基膦)钯 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 1.08h， 以69%的产率得到1-azido-2-(4-methyl-3-phenyl-penta-1,2,4-trienyl)-benzene
  参考文献：
  名称：

  Allenyl Azide Cycloaddition Chemistry. Photochemical Initiation and CuI Mediation Leads to Improved Regioselectivity

  摘要：

  Irradiation of 2-(3-alkenyl)allenylphenyl azides in the presence of excess Cul furnished functionalized 2,3-cyclopentenylindoles in good yield with only trace amounts of competitive C-N-bonded regioisomeric products. These results represent a significant departure from the modestto-nonexistent regioselectivity that attended thermal cyclization of these allenyl azide substrates.

  DOI：

  10.1021/ol800429j