methyl (2,3,4-tri-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-[(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)-(1->6)]-2-O-benzyl-α-D-glucopyranoside | 1220097-85-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl (2,3,4-tri-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-[(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)-(1->6)]-2-O-benzyl-α-D-glucopyranoside
• CAS: 1220097-85-7
• 化学式: C₇₅H₈₂O₁₅
• 分子量: 1223.47
• InChiKey: XJRDFCXMHVQUDO-PNEUHPFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.9
• 重原子数：
  90.0
• 可旋转键数：
  31.0
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  149.45
• 氢给体数：
  1.0
• 氢受体数：
  15.0

反应信息

• 作为反应物：
  描述：

  methyl (2,3,4-tri-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-[(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)-(1->6)]-2-O-benzyl-α-D-glucopyranoside 在 10% Pd(OH)2 on carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以68%的产率得到methyl (α-L-rhamnopyranosyl)-(1->3)-[(α-D-glucopyranosyl)-(1->6)]-α-D-glucopyranoside
  参考文献：
  名称：

  Synthesis of Tri- and Disaccharide Fragments Related to the O-Antigen of Enteropathogenic Escherichia Coli O158

  摘要：

  Chemical synthesis of a tri- and a disaccharide related to the O-antigen of enteropathogenic E. coli O158 was achieved in high yield. In the disaccharide (2), one D-galactosamine unit is present in 1,2-cis-linked and the other is in the trans-orientation, and both of them were prepared from the same intermediate by tuning the reaction solvent. Yields were considerably high in all steps.

  DOI：

  10.1080/07328300903477804
• 作为产物：
  描述：

  乙基beta-硫代吡喃葡萄糖苷四苄基 、 methyl (2,3,4-tri-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-2-O-benzyl-α-D-glucopyranoside 在 N-碘代丁二酰亚胺 、 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以80%的产率得到methyl (2,3,4-tri-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-[(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)-(1->6)]-2-O-benzyl-α-D-glucopyranoside
  参考文献：
  名称：

  Synthesis of Tri- and Disaccharide Fragments Related to the O-Antigen of Enteropathogenic Escherichia Coli O158

  摘要：

  Chemical synthesis of a tri- and a disaccharide related to the O-antigen of enteropathogenic E. coli O158 was achieved in high yield. In the disaccharide (2), one D-galactosamine unit is present in 1,2-cis-linked and the other is in the trans-orientation, and both of them were prepared from the same intermediate by tuning the reaction solvent. Yields were considerably high in all steps.

  DOI：

  10.1080/07328300903477804