1-(2,3,4,6-Tetra-O-benzyl-1-hydroxy-D-glucopyranos-1-yl)-3-[4-(tert-butyl-dimethyl-silyloxy)-benzyl]-4-methyl-benzene | 912917-82-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2,3,4,6-Tetra-O-benzyl-1-hydroxy-D-glucopyranos-1-yl)-3-[4-(tert-butyl-dimethyl-silyloxy)-benzyl]-4-methyl-benzene
• 英文别名: 1-(2,3,4,6-tetra-O-benzyl-1-hydroxy-D-glucopyranosyl)-3-[4-(tert-butyl-dimethyl-silyloxy)-benzyl]-4-methyl-benzene；(3R,4S,5R,6R)-2-[3-[[4-[tert-butyl(dimethyl)silyl]oxyphenyl]methyl]-4-methylphenyl]-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-ol
• CAS: 912917-82-9
• 化学式: C₅₄H₆₂O₇Si
• 分子量: 851.168
• InChiKey: SYDWUNZXGDDWRJ-KUHPJKDZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.49
• 重原子数：
  62
• 可旋转键数：
  19
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-(2,3,4,6-Tetra-O-benzyl-1-hydroxy-D-glucopyranos-1-yl)-3-[4-(tert-butyl-dimethyl-silyloxy)-benzyl]-4-methyl-benzene 在 三异丙基硅烷 、 三氟化硼乙醚 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以68%的产率得到1-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranos-1-yl)-3-(4-hydroxy-benzyl)-4-methyl-benzene
  参考文献：
  名称：

  Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture

  摘要：

  通用式I的葡萄糖吡喃基取代的((杂)环烷基乙炔基苄基)苯衍生物，其中基团R1至R6以及R7a、R7b、R7c根据权利要求1定义，包括其互变异构体、立体异构体、混合物及其盐。本发明的化合物适用于治疗代谢紊乱。

  公开号：

  US20070027092A1
• 作为产物：
  描述：

  5-内酯 在 正丁基锂 、 碳酸氢钠 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 6.5h， 生成 1-(2,3,4,6-Tetra-O-benzyl-1-hydroxy-D-glucopyranos-1-yl)-3-[4-(tert-butyl-dimethyl-silyloxy)-benzyl]-4-methyl-benzene
  参考文献：
  名称：

  Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture

  摘要：

  通用公式I的葡萄糖吡喃基取代的(杂)芳基乙炔基苯衍生物，其中基团R1至R6以及R7a、R7b、R7c根据权利要求1定义，包括其互变异构体、立体异构体、混合物及其盐。本发明的化合物适用于治疗代谢紊乱。

  公开号：

  US20060189548A1

文献信息

• Glucopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
  申请人：Eckhardt Matthias

  公开号：US20050209166A1

  公开（公告）日：2005-09-22

  Glucopyranosyl-substituted benzene derivatives of general formula I where the groups R 1 to R 6 as well as R 7a , R 7b , R 7c are defined herein and the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.

  通用公式I的葡萄糖吡喃基取代苯衍生物，其中R1至R6基团以及R7a、R7b、R7c在此定义，并且其互变异构体、立体异构体、混合物及盐。根据本发明的化合物适用于治疗代谢紊乱。
• Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
  申请人：Himmelsbach Frank

  公开号：US20070027092A1

  公开（公告）日：2007-02-01

  Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives of the general formula I where the groups R 1 to R 6 as well as R 7a , R 7b , R 7c are defined according to claim 1 , including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.

  通用式I的葡萄糖吡喃基取代的((杂)环烷基乙炔基苄基)苯衍生物，其中基团R1至R6以及R7a、R7b、R7c根据权利要求1定义，包括其互变异构体、立体异构体、混合物及其盐。本发明的化合物适用于治疗代谢紊乱。
• Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
  申请人：Himmelsbach Frank

  公开号：US20060234953A1

  公开（公告）日：2006-10-19

  Glucopyranosyloxy-substituted (heteroaryloxy-benzyl)-benzene compounds of the general formula I where the groups R 1 to R 6 as well as R 7a , R 7b , R 7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.

  通式I的葡萄糖吡喃氧基取代的（杂环氧基苄基）-苯化合物，其中基团R1至R6以及R7a、R7b、R7c根据权利要求1定义，包括其互变异构体、立体异构体、混合物及其盐。本发明的化合物适用于治疗代谢性疾病。
• GLUCOPYRANOSYL-SUBSTITUTED PHENYL DERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE
  申请人：Eckhardt Matthias

  公开号：US20090023913A1

  公开（公告）日：2009-01-22

  Glucopyranosyl-substituted benzene derivatives of general formula I where the groups R 1 to R 6 as well as R 7a , R 7b , R 7c are defined herein and the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.

  本发明涉及一般式I的葡萄糖吡喃糖基取代苯衍生物，其中基团R1到R6以及R7a、R7b、R7c如本文所定义，并且它们的互变异构体、立体异构体、混合物和盐。本发明的化合物适用于治疗代谢紊乱。
• GLUCOPYRANOSYL-SUBSTITUTED PHENYL DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE
  申请人：ECKHARDT Matthias

  公开号：US20090326215A1

  公开（公告）日：2009-12-31

  Glucopyranosyl-substituted benzene derivatives of general formula I where the groups R 1 to R 6 as well as R 7a , R 7b , R 7c are defined herein and the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.

  一般式为I的葡萄糖吡喃烷取代苯衍生物，其中基团R1至R6以及R7a、R7b、R7c在此被定义，其互变异构体、立体异构体、混合物和盐也被包括在内。本发明的化合物适用于治疗代谢紊乱。