5-(β-D-glucopyranosyl)tetrahydropyrimidin-2(1H)-one | 1401078-07-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(β-D-glucopyranosyl)tetrahydropyrimidin-2(1H)-one
• 英文别名: 5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-1,3-diazinan-2-one
• CAS: 1401078-07-6
• 化学式: C₁₀H₁₈N₂O₆
• 分子量: 262.263
• InChiKey: ZGFZDZLOMXPOHW-ZEBDFXRSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  131
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)malononitrile 在 platinum(IV) oxide 、 氢气 、 三甲基铝 、 sodium methylate 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 氯仿 为溶剂， 45.0 ℃ 、101.33 kPa 条件下， 反应 48.25h， 生成 5-(β-D-glucopyranosyl)tetrahydropyrimidin-2(1H)-one
  参考文献：
  名称：

  C-Glucosylated malonitrile as a key intermediate towards carbohydrate-based glycogen phosphorylase inhibitors

  摘要：

  Glycogen utilization involves glycogen phosphorylase, an enzyme which appears to be a potential target for the regulation of glycaemia, as the liver isoform is a major player for hepatic glucose output. A single C-glucosylated malonitrile allowed for the synthesis of three glucose-based derivatives namely bis-oxadiazoles, bis-amides and a C-glucosylated tetrahydropyrimidin-2-one. When evaluated as glycogen phosphorylase inhibitors, two of the synthesized compounds displayed inhibition in the sub-millimolar range. In silico studies revealed that only one out of the bis-amides obtained and the C-glucosylated tetrahydropyrimidin- 2-one may bind at the catalytic site. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.07.033

文献信息

• C-Glucosylated malonitrile as a key intermediate towards carbohydrate-based glycogen phosphorylase inhibitors
  作者：Sophie Feuillastre、Aikaterini S. Chajistamatiou、Constantinos Potamitis、Maria Zervou、Panagiotis Zoumpoulakis、Evangelia D. Chrysina、Jean-Pierre Praly、Sébastien Vidal

  DOI：10.1016/j.bmc.2012.07.033

  日期：2012.9

  Glycogen utilization involves glycogen phosphorylase, an enzyme which appears to be a potential target for the regulation of glycaemia, as the liver isoform is a major player for hepatic glucose output. A single C-glucosylated malonitrile allowed for the synthesis of three glucose-based derivatives namely bis-oxadiazoles, bis-amides and a C-glucosylated tetrahydropyrimidin-2-one. When evaluated as glycogen phosphorylase inhibitors, two of the synthesized compounds displayed inhibition in the sub-millimolar range. In silico studies revealed that only one out of the bis-amides obtained and the C-glucosylated tetrahydropyrimidin- 2-one may bind at the catalytic site. (C) 2012 Elsevier Ltd. All rights reserved.