(4,6-二甲氧基嘧啶-2-基)甲胺 | 771582-35-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (4,6-二甲氧基嘧啶-2-基)甲胺
• 英文名称: 4,6-dimethoxy-2-aminomethyl-pyrimidine
• 英文别名: (4,6-Dimethoxypyrimidin-2-YL)methanamine
• CAS: 771582-35-5
• 化学式: C₇H₁₁N₃O₂
• mdl: MFCD06213051
• 分子量: 169.183
• InChiKey: QRBXXPQJEYKYKQ-UHFFFAOYSA-N

物化性质

• 沸点：
  278.2±30.0 °C(Predicted)
• 密度：
  1.175±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  70.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (4,6-二甲氧基嘧啶-2-基)甲胺 、 4-三氟甲基烟酸 在 氯化亚砜 、 N,N-二甲基甲酰胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以34%的产率得到(4,6-dimethoxy-pyrimidin-2-ylmethyl)-4-trifluoromethyl-nicotinamide
  参考文献：
  名称：

  [DE] AZINYL-IMIDAZOAZINE UND AZINYLCARBOXAMIDE
  [EN] AZINYL IMIDAZOAZINE AND AZINYL CARBOXAMIDE
  [FR] IMIDAZOAZINES D'AZINYLE ET CARBOXAMIDES D'AZINYLE

  摘要：

  公开号：

  WO2005113553A3

文献信息

• PROCESS FOR PREPARING AMIC ACID ESTERS
  申请人：——

  公开号：US20030032667A1

  公开（公告）日：2003-02-13

  The present invention aims at providing a process for producing an amic acid ester useful as an intermediate for agrochemical, easily at a low cost industrially. The present invention provides a process for producing an amic acid ester represented by the following general formula (7): 1 (wherein A is a substituted or unsubstituted lower alkylene group or the like; R 1 is a substituted or unsubstituted lower alkyl group or the like; and R 3 is a hydrogen atom or a lower alkyl group), which process comprises reacting, in the presence of water, an amino acid represented by the following general formula (1): 2 (wherein A has the same definition as given above) with a halogenated carbonic acid ester represented by the following general formula (2): 3 (wherein R 1 has the same definition as given above and X is a halogen atom) to form an amide compound represented by the following general formula (3): 4 (wherein A and R 1 have the same definitions as given above), then reacting the amide compound with a halogenated carbonic acid ester represented by the following general formula (4): 5 (wherein R 2 is a substituted or unsubstituted lower alkyl group or the like; and X is a halogen atom) to form, in the system, a mixed acid anhydride represented by the following general formula (5): 6 (wherein A, R 1 and R 2 have the same definitions as given above), and reacting the mixed acid anhydride with an amine compound represented by the following general formula (6): 7 (wherein R 3 has the same definition as given above and Het is a substituted or unsubstituted heterocyclic group).

  本发明旨在提供一种用于农药中间体的制备的amic酸酯的工艺，该工艺在工业上易于低成本实现。本发明提供一种制备由下列通式（7）表示的amic酸酯的工艺：1（其中A是取代或未取代的较低烷基等；R1是取代或未取代的较低烷基等；R3是氢原子或较低烷基等），该工艺包括在水的存在下，将由下列通式（1）表示的氨基酸：2（其中A具有如上定义）与由下列通式（2）表示的卤代碳酸酯：3（其中R1具有如上定义，X是卤素原子）反应，形成由下列通式（3）表示的酰胺化合物：4（其中A和R1具有如上定义），然后将酰胺化合物与由下列通式（4）表示的卤代碳酸酯：5（其中R2是取代或未取代的较低烷基等；X是卤素原子）在体系中反应，形成由下列通式（5）表示的混合酸酐：6（其中A、R1和R2具有如上定义），并将混合酸酐与由下列通式（6）表示的胺化合物：7（其中R3具有如上定义，Het是取代或未取代的杂环基）反应。
• Azinyl Imidazoazine and Azinyl Carboxamide
  申请人：Schwarz Hans-Georg

  公开号：US20080293674A1

  公开（公告）日：2008-11-27

  The invention relates to azinylimidazoazines of structure (I) and their salts and N-oxides, whereby the symbols have the meanings given in the description, as well as to methods for their preparation and new intermediates. The invention further relates to the use of the compounds of structure (I) and the intermediates for the control of zoopests and undesirable micro-organisms.

  本发明涉及结构式（I）的氮杂咪唑啉基咪唑啉及其盐和N-氧化物，其中符号的含义如描述中所给，以及它们的制备方法和新中间体。本发明还涉及使用结构式（I）的化合物和中间体来控制动物害虫和不良微生物。
• AZINYL-IMIDAZOAZINE UND AZINYLCARBOXAMIDE
  申请人：Bayer CropScience Aktiengesellschaft

  公开号：EP1751152A2

  公开（公告）日：2007-02-14
• US6576765B2
  申请人：——

  公开号：US6576765B2

  公开（公告）日：2003-06-10
• [DE] AZINYL-IMIDAZOAZINE UND AZINYLCARBOXAMIDE<br/>[EN] AZINYL IMIDAZOAZINE AND AZINYL CARBOXAMIDE<br/>[FR] IMIDAZOAZINES D'AZINYLE ET CARBOXAMIDES D'AZINYLE
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2005113553A3

  公开（公告）日：2006-01-05