2-(4-methoxyphenyl)-7-(2-tetrahydro-1H-1-pyrrolylethoxy)-4-chromanone | 850152-79-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(4-methoxyphenyl)-7-(2-tetrahydro-1H-1-pyrrolylethoxy)-4-chromanone
• CAS: 850152-79-3
• 化学式: C₂₂H₂₅NO₄
• 分子量: 367.445
• InChiKey: SNQDULWTSPZJEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.88
• 重原子数：
  27.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  48.0
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-(4-methoxyphenyl)-7-(2-tetrahydro-1H-1-pyrrolylethoxy)-4-chromanone 、 苯甲醛 在 高氯酸 、 溶剂黄146 作用下， 反应 0.03h， 以100%的产率得到6-(4-Methoxy-phenyl)-3-(2-pyrrolidin-1-yl-ethoxy)-6H-chromeno[4,3-b]chromen-12-ylium; perchlorate
  参考文献：
  名称：

  Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells

  摘要：

  A series of new compounds structurally derived from 6a,12a-dihydro-6H,7H-[1]-benzopyran-[4,3-b]-benzopyran (homopterocarpane) was efficiently synthesized by reduction of the corresponding pyrilium salts obtained by treatment of selected flavanones and aldehydes with anhydrous HClO4. Cytotoxic effects on the human breast cancer cell line MCF-7 and antiestrogenic activity (only for compounds which resulted more active than tamoxifen (TAM)) on MCF-7 cells stimulated by 17beta-estradiol were evaluated. In vivo antiestrogenic activity and the relative binding affinity were also assessed. Some of the new compounds (4c, 4h, 4i and 4l) showed a biological activity in the micromolar range, and were more potent than TAM taken as the reference.

  DOI：

  10.1016/j.farmac.2004.09.006
• 作为产物：
  描述：

  1-(2-hydroxy-4-(2-tetrahydro-1H-1-pyrrolylethoxy)phenyl)-1-ethanone 在 盐酸 、 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 96.0h， 生成 2-(4-methoxyphenyl)-7-(2-tetrahydro-1H-1-pyrrolylethoxy)-4-chromanone
  参考文献：
  名称：

  Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells

  摘要：

  A series of new compounds structurally derived from 6a,12a-dihydro-6H,7H-[1]-benzopyran-[4,3-b]-benzopyran (homopterocarpane) was efficiently synthesized by reduction of the corresponding pyrilium salts obtained by treatment of selected flavanones and aldehydes with anhydrous HClO4. Cytotoxic effects on the human breast cancer cell line MCF-7 and antiestrogenic activity (only for compounds which resulted more active than tamoxifen (TAM)) on MCF-7 cells stimulated by 17beta-estradiol were evaluated. In vivo antiestrogenic activity and the relative binding affinity were also assessed. Some of the new compounds (4c, 4h, 4i and 4l) showed a biological activity in the micromolar range, and were more potent than TAM taken as the reference.

  DOI：

  10.1016/j.farmac.2004.09.006