2-((4'-methyl-2'-phenyl-[4,5'-bithiazol]-2-yl)amino)thiazol-4(5H)-one | 1210461-61-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-((4'-methyl-2'-phenyl-[4,5'-bithiazol]-2-yl)amino)thiazol-4(5H)-one
• CAS: 1210461-61-2
• 化学式: C₁₆H₁₂N₄OS₃
• 分子量: 372.495
• InChiKey: WMCUXTGISSALJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.28
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  67.24
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  2-((4'-methyl-2'-phenyl-[4,5'-bithiazol]-2-yl)amino)thiazol-4(5H)-one 、 苯甲醛 在 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 8.0h， 以63%的产率得到5-benzylidene-2-((4'-methyl-2'-phenyl-[4,5'-bithiazol]-2-yl)amino)thiazol-4(5H)-one
  参考文献：
  名称：

  Synthesis and Anticancer Activities of Some Thiazole Derivatives

  摘要：

  In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl] amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.

  DOI：

  10.1080/10426500802446181
• 作为产物：
  描述：

  硫氰酸铵 、 以 乙醇 为溶剂， 生成 2-((4'-methyl-2'-phenyl-[4,5'-bithiazol]-2-yl)amino)thiazol-4(5H)-one
  参考文献：
  名称：

  Synthesis and Anticancer Activities of Some Thiazole Derivatives

  摘要：

  In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl] amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.

  DOI：

  10.1080/10426500802446181