cyclohexylglycerin | 118043-43-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cyclohexylglycerin
• 英文别名: 1-cyclohexyl-propane-1,2,3-triol；(α.β.γ-Trioxy-propyl)-cyclohexan；α-Cyclohexyl-glycerin；1-Cyclohexyl-propan-1,2,3-triol；1-Cyclohexylpropane-1,2,3-triol
• CAS: 118043-43-9
• 化学式: C₉H₁₈O₃
• 分子量: 174.24
• InChiKey: LOCUWELCCSIXGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-环己基-2-丙醇 在 溴 、 potassium acetate 、 溶剂黄146 作用下， 生成 cyclohexylglycerin
  参考文献：
  名称：

  Sun Coke Company's heat recovery cokemaking technology. High coke quality and low environmental impact

  摘要：

  太阳焦炭公司的热回收炼焦技术历经 40 年的发展，现已成为满足未来全球炼焦需求的主导技术。届时将介绍有关混合煤测试和焦炭质量的大量数据。在环境方面，已经收集了大量的空气排放数据，并将与副产品焦化厂的空气排放数据进行比较。

  DOI：

  10.1051/metal:2003172

文献信息

• <i>In Situ</i> Generation of Zinc Carbenoids from Diazo Compounds and Zinc Salts: Asymmetric Synthesis of 1,2,3-Substituted Cyclopropanes
  作者：Sébastien R. Goudreau、André B. Charette

  DOI：10.1021/ja9074776

  日期：2009.11.4

  first enantioselective cyclopropanation of alkenes using zinc carbenoids generated in situ from diazo compounds and zinc salts is reported. This new method allows the highly enantio- and diastereoselective synthesis of 1,2,3-substituted cyclopropanes via aryl-substituted carbenoids. The first Simmons-Smith reaction using a catalytic amount of zinc to generate enantioenriched cyclopropane is also reported

  报道了使用由重氮化合物和锌盐原位生成的类锌化合物对烯烃进行的第一次对映选择性环丙烷化反应。这种新方法允许通过芳基取代的类卡宾对 1,2,3-取代的环丙烷进行高度对映选择性和非对映选择性合成。还报道了使用催化量的锌生成对映体富集的环丙烷的第一个 Simmons-Smith 反应。
• COSMETIC COMPOSITION
  申请人：AJINOMOTO CO., INC.

  公开号：US20160354294A1

  公开（公告）日：2016-12-08

  Provided is a cosmetic composition superior in antiseptic property and having high moisturizing property. A cosmetic composition containing (A) particular acylproline or a salt thereof, and (B) particular hydroxamic acid derivative, particular acetophenone derivative or diol compound.

  提供的是一种具有优异防腐性和高保湿性的化妆品组合物。该化妆品组合物包含（A）特定的酰基脯氨酸或其盐，以及（B）特定的羟肟酸衍生物、特定的苯乙酮衍生物或二元醇化合物。
• SUBSTITUTED CYCLOALKENE DERIVATIVE
  申请人：Kimura Tomio

  公开号：US20090233952A1

  公开（公告）日：2009-09-17

  [Object] To provide a substituted cycloalkene derivative having an action to suppress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a medicament containing them as an active ingredient, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation. [Solution] A compound represented by the general formula (I): wherein X and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A (the ring is 3- to 7-membered heterocyclyl ring or 3- to 7-membered cycloalkyl ring), each represents a hydrogen atom, or X and Y together represent a substituent of ring B. l and m, independently from each other, represent an integer of 0 to 3, and l+m is 1 to 3. R 1 is an aliphatic hydrocarbon group and the like which may be substituted with a group selected from Substituent group β and Substituent group γ. n represents an integer of 0 to 3. R 2 is a C 1 -C 6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. R 3 is a phenyl group, 5- to 6-membered heteroaryl group and the like which may be substituted with a group selected from Substituent group ε. R 5 is a C 1 -C 6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. Provided that in the case where R 3 is a phenyl group which may be substituted with a group selected from Substituent group ε, X and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A, or X and Y together represent a substituent of ring B.

  [目的] 提供一种替代环烯烃衍生物，具有抑制内毒素诱导的细胞内信号传导或细胞活化并抑制细胞对细胞内信号传导和细胞活化的反应，例如过量生成TNF-α等炎症介质，其药理学上可接受的盐，包含其作为活性成分的药物，其制备方法以及含有上述替代环烯烃衍生物作为活性成分的药物，其在预防和/或治疗与内毒素诱导的细胞内信号传导或细胞活化以及对细胞内信号传导和细胞活化的反应有关的疾病，例如败血症（败血性休克，弥漫性血管内凝血，多器官衰竭等）方面具有优越性。 [解决方案] 一种由通式（I）表示的化合物：其中，X和Y表示与它们结合的碳原子形成环A（环为3-至7成员的杂环或3-至7成员的环烷基环）的基团，每个表示氢原子，或X和Y一起表示环B的取代基。l和m，独立地，表示0至3的整数，且l+m为1至3。R1是脂肪烃基等，可以被从取代基组β和取代基组γ中选择的基团取代。n表示0至3的整数。R2是C1-C6烷基等，可以被从氢原子和取代基组β中选择的基团取代。R3是苯基，5-至6成员的杂环基等，可以被从取代基组ε中选择的基团取代。R5是C1-C6烷基等，可以被从氢原子和取代基组β中选择的基团取代。但在R3是苯基且可以被从取代基组ε中选择的基团取代的情况下，X和Y表示与它们结合的碳原子形成环A的基团，或X和Y一起表示环B的取代基。
• TOPICAL COMPOSITIONS WITH PRESERVATION SYSTEM
  申请人：DSM IP Assets B.V.

  公开号：EP3735958A1

  公开（公告）日：2020-11-11

  The present invention relates to topical compositions comprising a mixture of phytantriol and a C4-6alkyl glycerine as well as to the use of said mixture for the reduction and/ or prevention of microbial growth.

  本发明涉及由植物三醇和 C4-6 烷基甘油混合物组成的外用组合物，以及使用所述混合物减少和/或防止微生物生长。
• HYDROPHILIZED ORGANIC POWDER AND COSMETIC INCLUDING HYDROPHILIZED ORGANIC POWDER
  申请人：Miyoshi Kasei, Inc.

  公开号：EP4005552A1

  公开（公告）日：2022-06-01

  Provided are: a hydrophilized organic powder that is obtained by a hydrophilization treatment of a hydrophobic organic powder and has favorable properties; and a cosmetic that includes the hydrophilized organic powder. A hydrophilized organic powder that has a hydrophilizing-coat of polyoxyethylene (10) isostearyl ether on a hydrophobic organic powder is provided. Further, a cosmetic that includes the hydrophilized organic powder is provided. The hydrophobic organic powder is preferably an organic resin powder or a metallic soap powder, or a combination thereof.

  本发明提供了：一种通过对疏水有机粉末进行亲水化处理而获得的、具有良好特性的亲水有机粉末；以及一种包含该亲水有机粉末的化妆品。本发明提供了一种在疏水性有机粉末上具有聚氧乙烯（10）异硬脂醇醚亲水涂层的亲水有机粉末。此外，还提供了一种包含该亲水有机粉末的化妆品。疏水性有机粉末最好是有机树脂粉末或金属皂粉，或它们的组合。