5-chloro-2-methyl-3,4-dihydropyrido[2,3-g]quinoxalin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-chloro-2-methyl-3,4-dihydropyrido[2,3-g]quinoxalin-3-one
• 英文别名: 5-chloro-2-methyl-4H-pyrido[3,2-g]quinoxalin-3-one
• 化学式: C₁₂H₈ClN₃O
• 分子量: 245.668
• InChiKey: ALGYQRMORNONAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  7-amino-8-chloro-6-nitroquinoline 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 63.0h， 生成 5-chloro-2-methyl-3,4-dihydropyrido[2,3-g]quinoxalin-3-one
  参考文献：
  名称：

  Novel functionalized pyrido[2,3-g]quinoxalinones as antibacterial, antifungal and anticancer agents

  摘要：

  A series of twelve novel pyrido[2,3-g]quinoxalinones (3-14), variously substituted at the C-3 position, was synthesized, structurally determined and submitted to a preliminary in vitro evaluation for antibacterial, anticandida and anticancer activities. Results of the antimicrobial screening showed that all compounds, with the exception of 6, 11 and 12, exhibited interesting activity against all strains tested; while compound 10 was found to have encouraging in vitro anticancer activity at a concentration of 10(-4) M. (C) 2001 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01161-2