N-(5-chloro-6-methoxy-[8]quinolyl)-N'-isopropyl-pentanediyldiamine | 7467-66-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(5-chloro-6-methoxy-[8]quinolyl)-N'-isopropyl-pentanediyldiamine
• 英文别名: N-(5-Chlor-6-methoxy-[8]chinolyl)-N'-isopropyl-pentandiyldiamin；N-(5-chloro-6-methoxyquinolin-8-yl)-N'-propan-2-ylpentane-1,5-diamine
• CAS: 7467-66-5
• 化学式: C₁₈H₂₆ClN₃O
• 分子量: 335.877
• InChiKey: PZTUPXDSJRFMKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异丙戊二胺喹 在 氯 作用下， 以 溶剂黄146 为溶剂， 以35%的产率得到N-(5-chloro-6-methoxy-[8]quinolyl)-N'-isopropyl-pentanediyldiamine
  参考文献：
  名称：

  8-Aminoquinolines as anticoccidials-I

  摘要：

  The proposed ring metabolites of the 8-aminoquinoline antimalarial, pentaquine, 1, have been synthesised and their biological activity as anticoccidial agents investigated in vivo. Several analogues in which this metabolic pathway had been blocked were also synthesised and their anticoccidial activity measured. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10024-5

文献信息

• Synthetic Antimalarials. 8-(5-Isopropylaminoamylamino)-6-methoxyquinoline (SN-13,276)¹ and Some Related Compounds²
  作者：Nathan L. Drake、John van Hook、John A. Garman、Robert Hayes、R. Johnson、G. W. Kelley、Sidney Melamed、Richard M. Peck

  DOI：10.1021/ja01212a041

  日期：1946.8
• 8-Aminoquinolines as anticoccidials-I
  作者：Richard E. Armer、Jacqueline S. Barlow、Christopher J. Dutton、David H.J. Greenway、Sean D.W. Greenwood、Nita Lad、Ivan Tommasini

  DOI：10.1016/s0960-894x(97)10024-5

  日期：1997.10

  The proposed ring metabolites of the 8-aminoquinoline antimalarial, pentaquine, 1, have been synthesised and their biological activity as anticoccidial agents investigated in vivo. Several analogues in which this metabolic pathway had been blocked were also synthesised and their anticoccidial activity measured. (C) 1997 Elsevier Science Ltd.