(5-methoxy-1,3,3-trimethyl-cyclohexyl)-methylamine | 1363594-92-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (5-methoxy-1,3,3-trimethyl-cyclohexyl)-methylamine
• 英文别名: (5-Methoxy-1,3,3-trimethylcyclohexyl)methanamine
• CAS: 1363594-92-6
• 化学式: C₁₁H₂₃NO
• 分子量: 185.31
• InChiKey: UYJCUWSITUGUOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-溴-5-氟三氟甲苯 、 (5-methoxy-1,3,3-trimethyl-cyclohexyl)-methylamine 在 potassium phosphate 、 copper(l) iodide 、 L-脯氨酸 作用下， 以 二甲基亚砜 为溶剂， 生成 (3-fluoro-5-trifluoromethyl-phenyl)-(cis-1,5)-5-methoxy-(1,3,3-trimethyl-cyclohexylmethyl)-amine
  参考文献：
  名称：

  COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA

  摘要：

  化合物的化学式（I）及其药用盐，其中R1至R4和Ar如描述和权利要求中所定义，可用作药物。

  公开号：

  US20110195979A1

文献信息

• [EN] COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA<br/>[FR] COMPOSÉS POUR LE TRAITEMENT ET LA PRÉVENTION DE LA GRIPPE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2011094953A1

  公开（公告）日：2011-08-11

  A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.

  化合物的化学式（I）及其药学上可接受的盐，其中R1至R4和Ar如描述和索赔中定义的那样，可用作药物。
• Methods of Making Fused Ring Compounds
  申请人：Transitions Optical, Inc.

  公开号：US20170050909A1

  公开（公告）日：2017-02-23

  The present invention relates to methods of making fused ring compounds, such as indeno-fused naphthols, and fused ring indenopyran compounds, such as indeno-fused naphthopyrans, that each employ an unsaturated compound represented by the following Formula II. Referring to the unsaturated compound of Formula II: Ring-A can be selected from optionally substituted aryl (e.g., phenyl); m can be, for example, from 0 to 4; R 1 for each m can be selected from optionally substituted hydrocarbyl (e.g., C 1 -C 6 alkyl) optionally interrupted with at least one linking group (e.g., —O—); and R 3 and R 16 can each be independently selected from, for example, hydrogen or optionally substituted hydrocarbyl, such as C 1 -C 8 alkyl. When Ring-A is a phenyl group, the unsaturated compound represented by Formula II can be referred to as an unsaturated indanone acid/ester compound, or an indenone acid/ester compound (depending on whether R 16 is hydrogen, or an optionally substituted hydrocarbyl group).