cis,trans-2,5-dimethylcyclopentanol | 65378-78-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cis,trans-2,5-dimethylcyclopentanol
• 英文别名: (2R,5R)-2,5-dimethylcyclopentan-1-ol
• CAS: 65378-78-1
• 化学式: C₇H₁₄O
• 分子量: 114.188
• InChiKey: DJGMEPWATAGUNV-PHDIDXHHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,5-二甲基-环戊酮 在 lithium aluminium tetrahydride 作用下， 生成 cis,trans-2,5-dimethylcyclopentanol
  参考文献：
  名称：

  Reactions of methyl-substituted cyclopentanones with lithium aluminum hydride and methyllithium. Structural determinations and proton nuclear magnetic resonance study of the reaction products

  摘要：

  DOI：

  10.1021/jo00405a020

文献信息

• Orally active renin inhibitors
  申请人：PFIZER INC.

  公开号：EP0438233A2

  公开（公告）日：1991-07-24

  This invention relates to compounds of the formula wherein Q, Z, D, E, R3, R4, R5 and R6 are defined as below, and the pharmaceutically acceptable salts thereof are disclosed. The compounds are useful as antihypertensive agents.

  本发明涉及如下式的化合物 其中 Q、Z、D、E、R3、R4、R5 和 R6 的定义如下，本发明公开了其药学上可接受的盐类。这些化合物可用作降压药。
• SULFONAMIDES DERIVED FROM TRICYCLYL-2-AMINOCYCLOALKANOLS AS ANTICANCER AGENTS
  申请人：ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

  公开号：US20170015625A1

  公开（公告）日：2017-01-19

  A genus of arylsulfonamide derivatives of aminocycloalkanols is disclosed. The compounds are of the following genus: The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a monotherapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.
• US5442044A
  申请人：——

  公开号：US5442044A

  公开（公告）日：1995-08-15
• US9937186B2
  申请人：——

  公开号：US9937186B2

  公开（公告）日：2018-04-10