3-Cyanomethyl-1,4,5,8-tetramethoxy-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile | 885553-06-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 3-Cyanomethyl-1,4,5,8-tetramethoxy-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile
• 英文别名: 3-(Cyanomethyl)-1,4,5,8-tetramethoxy-9-trimethylsilyloxyfluorene-9-carbonitrile
• CAS: 885553-06-0
• 化学式: C₂₃H₂₆N₂O₅Si
• 分子量: 438.555
• InChiKey: XPYXMFPPCRAKCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.39
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  93.7
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3-Cyanomethyl-1,4,5,8-tetramethoxy-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile 在 三乙基硅烷 、 三氟化硼乙醚 、 氢溴酸 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 3-Carboxymethyl-1,4,5,8-tetrahydroxy-9H-fluorene-9-carboxylic acid
  参考文献：
  名称：

  Synthesis of hipposudoric and norhipposudoric acids: the pigments responsible for the color reaction of the red sweat of Hippopotamus amphibius

  摘要：

  Highly unstable pigments, hipposudoric acid and norhipposudoric acid, isolated from the red sweat of hippopotamus were synthesized using the Pschorr reaction for the construction of the fluorene nucleus as the key step and the careful oxidation in the last step. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.02.042
• 作为产物：
  描述：

  2,5-二甲氧基甲苯 在 N-溴代丁二酰亚胺(NBS) 、 四丁基氟化铵 、 溴 、 叔丁基锂 、 sodium acetate 、 铁粉 、 溶剂黄146 、 pyridinium chlorochromate 、 亚硝酸异戊酯 、 过氧化苯甲酰 作用下， 以 四氢呋喃 、 二氯甲烷 、 正戊烷 、 苯 为溶剂， 反应 40.0h， 生成 3-Cyanomethyl-1,4,5,8-tetramethoxy-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile
  参考文献：
  名称：

  Synthesis of hipposudoric and norhipposudoric acids: the pigments responsible for the color reaction of the red sweat of Hippopotamus amphibius

  摘要：

  Highly unstable pigments, hipposudoric acid and norhipposudoric acid, isolated from the red sweat of hippopotamus were synthesized using the Pschorr reaction for the construction of the fluorene nucleus as the key step and the careful oxidation in the last step. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.02.042

文献信息

• Synthesis of hipposudoric and norhipposudoric acids: the pigments responsible for the color reaction of the red sweat of Hippopotamus amphibius
  作者：Yoko Saikawa、Kai Moriya、Kimiko Hashimoto、Masaya Nakata

  DOI：10.1016/j.tetlet.2006.02.042

  日期：2006.4

  Highly unstable pigments, hipposudoric acid and norhipposudoric acid, isolated from the red sweat of hippopotamus were synthesized using the Pschorr reaction for the construction of the fluorene nucleus as the key step and the careful oxidation in the last step. (c) 2006 Elsevier Ltd. All rights reserved.