(5S,7S)-8-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-8-methyl-3-oxo-nonanoic acid ethyl ester | 152426-92-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5S,7S)-8-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-8-methyl-3-oxo-nonanoic acid ethyl ester
• 英文别名: ethyl (5S,7S)-7-[tert-butyl(dimethyl)silyl]oxy-8-[2-[[(2S,6R)-4,4-dimethoxy-6-(phenylmethoxymethyl)oxan-2-yl]methyl]-1,3-dithian-2-yl]-5-hydroxy-8-methyl-3-oxononanoate
• CAS: 152426-92-1
• 化学式: C₃₈H₆₄O₉S₂Si
• 分子量: 757.138
• InChiKey: ZXQRFTYMHOMNLZ-PPESYSCFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.78
• 重原子数：
  50
• 可旋转键数：
  21
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  160
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  (5S,7S)-8-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-8-methyl-3-oxo-nonanoic acid ethyl ester 在 溶剂黄146 、 tetramethylammonium triacetoxyborohydride 作用下， 以 乙腈 为溶剂， 生成 (3R,5R,7S)-8-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-7-(tert-butyl-dimethyl-silanyloxy)-3,5-dihydroxy-8-methyl-nonanoic acid ethyl ester
  参考文献：
  名称：

  Synthetic studies on bryostatins, antineoplastic metabolites: Convergent synthesis of the C1-C16 fragment shared by all of the bryostatin family

  摘要：

  The C1-C-16 fragment of bryostatins could successfully be synthesized by tandem connection of the appropriate three fragments and effective introduCtion of the alpha,beta-unsaturated esters at the C-13 position.

  DOI：

  10.1016/s0040-4039(00)74063-9
• 作为产物：
  描述：

  [(2R,3R)-3-(2-methyl-1-phenylmethoxypropan-2-yl)oxiran-2-yl]methanol 在 钯 咪唑 、 六甲基磷酰三胺 、 pyridine-SO3 complex 、 乙醇 、 氢气 、 叔丁基锂 、 4-甲基苯磺酸吡啶 、 二甲基亚砜 、 三乙胺 、 红铝 、 magnesium bromide 、 lithium iodide 、 lithium diisopropyl amide 作用下， 以 甲醇 、 乙醚 、 乙醇 、 甲苯 为溶剂， 生成 (5S,7S)-8-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-8-methyl-3-oxo-nonanoic acid ethyl ester
  参考文献：
  名称：

  Synthetic studies on bryostatins, antineoplastic metabolites: Convergent synthesis of the C1-C16 fragment shared by all of the bryostatin family

  摘要：

  The C1-C-16 fragment of bryostatins could successfully be synthesized by tandem connection of the appropriate three fragments and effective introduCtion of the alpha,beta-unsaturated esters at the C-13 position.

  DOI：

  10.1016/s0040-4039(00)74063-9

文献信息

• Synthetic studies on bryostatins, antineoplastic metabolites: Convergent synthesis of the C1-C16 fragment shared by all of the bryostatin family
  作者：Ken Ohmori、Takayuki Suzuki、Kazuyuki Miyazawa、Shigeru Nishiyama、Shosuke Yamamura

  DOI：10.1016/s0040-4039(00)74063-9

  日期：1993.7

  The C1-C-16 fragment of bryostatins could successfully be synthesized by tandem connection of the appropriate three fragments and effective introduCtion of the alpha,beta-unsaturated esters at the C-13 position.