(2R,6S)-2-Benzyloxymethyl-6-{2-[(S)-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-1,1-dimethyl-butyl]-[1,3]dithian-2-ylmethyl}-4,4-dimethoxy-tetrahydro-pyran | 152426-88-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,6S)-2-Benzyloxymethyl-6-{2-[(S)-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-1,1-dimethyl-butyl]-[1,3]dithian-2-ylmethyl}-4,4-dimethoxy-tetrahydro-pyran
• 英文别名: tert-butyl-[(3S)-1-[tert-butyl(dimethyl)silyl]oxy-4-[2-[[(2S,6R)-4,4-dimethoxy-6-(phenylmethoxymethyl)oxan-2-yl]methyl]-1,3-dithian-2-yl]-4-methylpentan-3-yl]oxy-dimethylsilane
• CAS: 152426-88-5
• 化学式: C₃₈H₇₀O₆S₂Si₂
• 分子量: 743.273
• InChiKey: ZGIMHTNNOXLMFF-DSPMFFIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.52
• 重原子数：
  48
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  106
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (2R,6S)-2-Benzyloxymethyl-6-{2-[(S)-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-1,1-dimethyl-butyl]-[1,3]dithian-2-ylmethyl}-4,4-dimethoxy-tetrahydro-pyran 在 pyridine-SO3 complex 、 4-甲基苯磺酸吡啶 、 二甲基亚砜 、 三乙胺 作用下， 以 甲醇 为溶剂， 生成 (3S)-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-[[(2S,6R)-4,4-dimethoxy-6-(phenylmethoxymethyl)oxan-2-yl]methyl]-1,3-dithian-2-yl]-4-methylpentanal
  参考文献：
  名称：

  Synthetic studies on bryostatins, antineoplastic metabolites: Convergent synthesis of the C1-C16 fragment shared by all of the bryostatin family

  摘要：

  The C1-C-16 fragment of bryostatins could successfully be synthesized by tandem connection of the appropriate three fragments and effective introduCtion of the alpha,beta-unsaturated esters at the C-13 position.

  DOI：

  10.1016/s0040-4039(00)74063-9
• 作为产物：
  描述：

  [(2R,3R)-3-(2-methyl-1-phenylmethoxypropan-2-yl)oxiran-2-yl]methanol 在 钯 咪唑 、 六甲基磷酰三胺 、 氢气 、 叔丁基锂 、 红铝 、 magnesium bromide 作用下， 以 乙醚 、 乙醇 、 甲苯 为溶剂， 生成 (2R,6S)-2-Benzyloxymethyl-6-{2-[(S)-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-1,1-dimethyl-butyl]-[1,3]dithian-2-ylmethyl}-4,4-dimethoxy-tetrahydro-pyran
  参考文献：
  名称：

  Synthetic studies on bryostatins, antineoplastic metabolites: Convergent synthesis of the C1-C16 fragment shared by all of the bryostatin family

  摘要：

  The C1-C-16 fragment of bryostatins could successfully be synthesized by tandem connection of the appropriate three fragments and effective introduCtion of the alpha,beta-unsaturated esters at the C-13 position.

  DOI：

  10.1016/s0040-4039(00)74063-9

文献信息

• Synthetic studies on bryostatins, antineoplastic metabolites: Convergent synthesis of the C1-C16 fragment shared by all of the bryostatin family
  作者：Ken Ohmori、Takayuki Suzuki、Kazuyuki Miyazawa、Shigeru Nishiyama、Shosuke Yamamura

  DOI：10.1016/s0040-4039(00)74063-9

  日期：1993.7

  The C1-C-16 fragment of bryostatins could successfully be synthesized by tandem connection of the appropriate three fragments and effective introduCtion of the alpha,beta-unsaturated esters at the C-13 position.