| 577786-70-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 577786-70-0
• 化学式: C₅₉H₁₀₆N₆O₂₄S₂
• 分子量: 1347.65
• InChiKey: PYRAQMHMENMDCB-XQQLXDAOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.73
• 重原子数：
  91.0
• 可旋转键数：
  22.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  406.74
• 氢给体数：
  13.0
• 氢受体数：
  26.0

反应信息

• 作为反应物：
  描述：

  2-Bromo-N-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(4-nitro-phenyl)-ethyl]-acetamide 、 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 以87%的产率得到
  参考文献：
  名称：

  An Approach To Enhance Specificity against RNA Targets Using Heteroconjugates of Aminoglycosides and Chloramphenicol (or Linezolid)

  摘要：

  We describe the design and synthesis of new heterodimeric conjugates, which are comprised of a neomycin B (Neo) stem-binding component and a chloramphenicol (Cam) or linezolid (Lnz) loop-binding component. Some of the heterodimeric conjugates display enhanced affinities to RNA targets and that binding occurs in both stem and loop regions of the RNA. In addition, the results of foot-printing and mutation studies suggest that the enhanced binding affinity of the conjugates is RNA sequence-specific.

  DOI：

  10.1021/ja038937y
• 作为产物：
  描述：

  1,6-己二硫醇 、 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 9.0h， 以85%的产率得到
  参考文献：
  名称：

  An Approach To Enhance Specificity against RNA Targets Using Heteroconjugates of Aminoglycosides and Chloramphenicol (or Linezolid)

  摘要：

  We describe the design and synthesis of new heterodimeric conjugates, which are comprised of a neomycin B (Neo) stem-binding component and a chloramphenicol (Cam) or linezolid (Lnz) loop-binding component. Some of the heterodimeric conjugates display enhanced affinities to RNA targets and that binding occurs in both stem and loop regions of the RNA. In addition, the results of foot-printing and mutation studies suggest that the enhanced binding affinity of the conjugates is RNA sequence-specific.

  DOI：

  10.1021/ja038937y

文献信息

• A strategy for the design of selective RNA binding agents. Preparation and RRE RNA binding affinities of a neomycin-peptide nucleic acid heteroconjugate library
  作者：Soonsil Hyun、Kyung Hyun Lee、Jaehoon Yu

  DOI：10.1016/j.bmcl.2006.06.094

  日期：2006.9

  We have successfully developed a new strategy for RNA ligand design, which applies the antisense concept to enhance and make more specific loop region interactions while at the same time preserving stem region anchoring. The heteroconjugates, prepared in this effort, have proven to be the most specific small molecule ligands against RRE RNA that have been uncovered to date. (c) 2006 Elsevier Ltd. All rights reserved.