6,6'-硫代二己酸 | 10341-18-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 6,6'-硫代二己酸
• 英文名称: 6,6'-thiodihexanoic acid
• 英文别名: 6,6'-Thiodicapronsaeure；Di-(5-carboxy-pentyl)-sulfid；7-thia-tridecanedioic acid；Bis-(5-carboxy-pentyl)-sulfid；6,6'-Thio-dihexansaeure；7-Thia-tridecandisaeure；6-(5-Carboxypentylsulfanyl)hexanoic acid
• CAS: 10341-18-1
• 化学式: C₁₂H₂₂O₄S
• 分子量: 262.37
• InChiKey: IWGZYWDZEDWMCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  99.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6,6'-硫代二己酸 在 氯化亚砜 、 间氯过氧苯甲酸 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 生成 4,6-(1,17-(2,16-diaza-3,15-dioxo-9-dioxothia-heptadecamethylene))-3,7-dimethyl-1,5-diazabicyclo<3.3.0>octa-3,6-diene-2,8-dione
  参考文献：
  名称：

  Bimane cyclic esters, possible stereologues of trypanothione as antitrypanosomal agents. Bimanes 29

  摘要：

  Tricyclic esters derived from bimanes have been synthesized with ring sizes near or equal to that of trypanothione disulfide (T(S)(2)), a bis-glutathionylspermidine that is involved in regulating the thiol status of Leishmania and other trypanosomatids. Modest activity for many of the compounds against Leishmania donovani with a maximum at the T(S)(2) ring size suggests that the esters act as T(S)(2) surrogates. However, no inhibition of T(S)(2)-reductase is observed for a number of the compounds. A series of tricyclic bimane amides with structures more closely analogous to T(S)2 are inactive in biological tests, New approaches were developed for the synthesis of the amides. The surprising effectiveness of the cyclic ester synthesis is explained. Acid chloride formation catalyzed by sulfides is briefly described.

  DOI：

  10.1016/0223-5234(96)88283-3
• 作为产物：
  描述：

  己内酰胺 在 sodium sulfide 、 水 作用下， 生成 6,6'-硫代二己酸
  参考文献：
  名称：

  DE944790

  摘要：

  公开号：

文献信息

• Redox responsive paclitaxel dimer for programmed drug release and selectively killing cancer cells
  作者：Rui Xia、Qing Pei、Jian Wang、Zhanfeng Wang、Xiuli Hu、Zhigang Xie

  DOI：10.1016/j.jcis.2020.07.086

  日期：2020.11

  investigated and proved to be promising prospects for efficient cancer therapy due to the abnormal high level of reactive oxygen species and glutathione in tumor microenvironment. Herein, three paclitaxel dimers (named as PTX2-R, R = S, Se and Te) bridged with alkyl sulfide, selenide or telluride are synthesized. These dimers can self-assemble into stable uniform nanoparticles (named as PTX2-R NPs, R = S

  由于肿瘤微环境中异常高水平的活性氧和谷胱甘肽，氧化还原刺激响应药物递送系统已被广泛研究并被证明是有效癌症治疗的有希望的前景。本文合成了与烷基硫、硒化物或碲化物桥接的三种紫杉醇二聚体（命名为 PTX 2 -R、R = S、Se 和 Te）。这些二聚体可以自组装成稳定的均匀纳米颗粒（命名为 PTX 2-R NPs，R = S，Se 和 Te）具有令人印象深刻的高载药量。正如预期的那样，硫/硒/碲键表现出不同的氧化还原反应，从而影响药物释放和细胞毒性。值得注意的是，碲桥紫杉醇二聚体对过氧化氢表现出超敏感性，过氧化氢在随后的二硫苏糖醇刺激下迅速裂解成两个紫杉醇。我们的研究结果提供了对硫属元素的氧化还原敏感性的深入了解，并为程序性药物释放的生物氧化还原条件提供了合理的设计策略。
• Water-based ink for ink jet recording
  申请人：Brother Kogyo Kabushiki Kaisha

  公开号：EP2354196A1

  公开（公告）日：2011-08-10

  A water-based ink for ink jet recording, containing: a coloring agent; water; and a water-soluble organic solvent. The coloring agent contains a phosphate group-modified self-dispersing pigment. The water-based ink further contains at least one selected from the group consisting of boric acid, diglycolic acid, and a chelating agent.

  一种用于喷墨记录的水基墨水，包含：着色剂、水和水溶性有机溶剂。着色剂含有磷酸基团改性的自分散颜料。水基墨水还含有至少一种硼酸、二乙醇酸和螯合剂。
• Water-Based Ink for Ink Jet Recording
  申请人：AOYAMA Michiko

  公开号：US20110187799A1

  公开（公告）日：2011-08-04

  A water-based ink for ink jet recording, containing: a coloring agent; water; and a water-soluble organic solvent. The coloring agent contains a phosphate group-modified self-dispersing pigment. The water-based ink further contains at least one selected from the group consisting of boric acid, diglycolic acid, and a chelating agent.
• US4699955A
  申请人：——

  公开号：US4699955A

  公开（公告）日：1987-10-13
• US4701501A
  申请人：——

  公开号：US4701501A

  公开（公告）日：1987-10-20