6-ethoxy-2-hydrazinopyridine | 1211595-93-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-ethoxy-2-hydrazinopyridine
• 英文别名: (6-ethoxypyridin-2-yl)hydrazine
• CAS: 1211595-93-5
• 化学式: C₇H₁₁N₃O
• 分子量: 153.184
• InChiKey: AMACKJNPJPBXEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  60.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-ethoxy-2-hydrazinopyridine 、 在 溶剂黄146 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 (7R)-7-(3,4-dichlorophenyl)-6-[2-(6-ethoxypyridin-2-yl)-1,2,4-triazol-3-yl]-5-methyl-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidine
  参考文献：
  名称：

  Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists

  摘要：

  Previously disclosed C6 amido and benzimidazole dihydropyrazolopyrimidines were potent and selective blockers of I-Kur current. Syntheses and SAR for C6 triazolo and imidazo dihydropyrazolopyrimidines series are described. Trifluoromethylcyclohexyl N(1) triazole, compound 51, was identified as a potent and selective K(v)1.5 inhibitor with an acceptable PK and liability profile. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.064
• 作为产物：
  描述：

  2-氯-6-乙氧基吡啶 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 72.0h， 生成 6-ethoxy-2-hydrazinopyridine
  参考文献：
  名称：

  Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists

  摘要：

  Previously disclosed C6 amido and benzimidazole dihydropyrazolopyrimidines were potent and selective blockers of I-Kur current. Syntheses and SAR for C6 triazolo and imidazo dihydropyrazolopyrimidines series are described. Trifluoromethylcyclohexyl N(1) triazole, compound 51, was identified as a potent and selective K(v)1.5 inhibitor with an acceptable PK and liability profile. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.064

文献信息

• Condensed pyrazole derivatives, process for producing the same and use thereof
  申请人：——

  公开号：US20030187014A1

  公开（公告）日：2003-10-02

  Novel pharmaceutical compositions for inhibiting Th2-selective immune response and pharmaceutical compositions for inhibiting cyclooxygenase comprising condensed pyrazole derivatives represented by the general formula (I): 1 or salts thereof.

  用于抑制Th2选择性免疫应答的新型药物组合物和包括由一般式(I)表示的紧缩吡唑烷衍生物的药物组合物，或其盐。
• CONDENSED PYRAZOLE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP1270572A1

  公开（公告）日：2003-01-02

  Novel pharmaceutical compositions for inhibiting Th2-selective immune response and pharmaceutical compositions for inhibiting cyclooxygenase comprising condensed pyrazole derivatives represented by the general formula (I): or salts thereof.

  用于抑制 Th2 选择性免疫反应的新型药物组合物和用于抑制环氧化酶的药物组合物，包含由通式（I）代表的缩合吡唑衍生物： 或其盐类。
• US6949648B2
  申请人：——

  公开号：US6949648B2

  公开（公告）日：2005-09-27
• Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists
  作者：Heather J. Finlay、Ji Jiang、Yolanda Caringal、Alexander Kover、Mary Lee Conder、Dezhi Xing、Paul Levesque、Timothy Harper、Mei Mann Hsueh、Karnail Atwal、Michael Blanar、Ruth Wexler、John Lloyd

  DOI：10.1016/j.bmcl.2013.01.064

  日期：2013.3

  Previously disclosed C6 amido and benzimidazole dihydropyrazolopyrimidines were potent and selective blockers of I-Kur current. Syntheses and SAR for C6 triazolo and imidazo dihydropyrazolopyrimidines series are described. Trifluoromethylcyclohexyl N(1) triazole, compound 51, was identified as a potent and selective K(v)1.5 inhibitor with an acceptable PK and liability profile. (C) 2013 Elsevier Ltd. All rights reserved.