2-methylsulfanyl-3-nitropyrazolo[1,5-a]pyridine | 63432-37-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 2-methylsulfanyl-3-nitropyrazolo[1,5-a]pyridine
• 英文别名: 2-Methylthio-1-nitropyrazolo<1,5-a>pyridin；2-(methylthio)-3-nitropyrazolo[1,5-a]pyridine；2-methylsulphanyl-3-nitro-pyrazolo[1,5-a]pyridine
• CAS: 63432-37-1
• 化学式: C₈H₇N₃O₂S
• 分子量: 209.228
• InChiKey: DBOKFPYOOZIULN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  88.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methylsulfanyl-3-nitropyrazolo[1,5-a]pyridine 在 四(三苯基膦)钯 、 正丁基锂 、 barium hydroxide octahydrate 、 溶剂黄146 、 三乙胺 、 锌 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 乙醇 、 正己烷 、 二氯甲烷 、 水 为溶剂， 反应 21.5h， 生成 tert-butyl (7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-(methylthio)pyrazolo[1,5-a]pyridin-3-yl)carbamate
  参考文献：
  名称：

  Synthesis and Structure–Activity Relationships of Pyrazolo[1,5-a]pyridine Derivatives: Potent and Orally Active Antagonists of Corticotropin-Releasing Factor 1 Receptor

  摘要：

  Design, synthesis, and structure activity relationships of a series of 3-dialkylamino-7-phenyl pyrazolo[1,5-a]pyridines (I) as selective antagonists of the corticotropin-releasing factor 1 (CRF1) receptor are described. The most prominent compound to emerge from this work, 46 (E2508), exhibits potent in vitro activity, excellent drug-like properties, and robust oral efficacy in animal models of stress-related disorders. It has advanced into clinical trials.

  DOI：

  10.1021/jm300259r
• 作为产物：
  描述：

  1,1-双(甲硫基)-2-亚硝基乙烯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成 2-methylsulfanyl-3-nitropyrazolo[1,5-a]pyridine
  参考文献：
  名称：

  Composition for dyeing keratin fibers comprising at least one cationic 3-amino-pyrazolopyridine derivative, and methods of use thereof

  摘要：

  本公开涉及一种用于染色角蛋白纤维（如头发）的组合物，包括至少一种氧化碱，所述氧化碱选自阳离子3-氨基吡唑-1,5-吡啶衍生物及其加成盐，并且使用该组合物的方法。本公开还涉及阳离子3-氨基吡唑-1,5-吡啶衍生物及其加成盐。

  公开号：

  US20070136959A1

文献信息

• Composition for the dyeing of keratin fibers comprising at least one 3-amino-pyrazolopyridine derivatives
  申请人：Fadli Aziz

  公开号：US20070143935A1

  公开（公告）日：2007-06-28

  Disclosed herein is a composition for the dyeing of keratin fibers, for example, human keratin fibers such as the hair, comprising at least one 3-amino pyrazolo-[1,5-a]-pyridine derivative or one of its addition salts and a method employing this derivative. The composition of the present disclosure makes it possible to obtain coloration in various shades that is powerful, chromatic, and aesthetic, with low selectivity and with good resistance to various aggressive factors to which the hair may be subjected, such as shampoos, the light, sweat and permanent shaping.

  本公开涉及一种用于染色角蛋白纤维的组合物，例如，人类角蛋白纤维，如头发，包括至少一种3-氨基吡唑并[1,5-a]-吡啶衍生物或其加合盐以及采用该衍生物的方法。本公开的组合物使得可以获得各种色调的着色，具有强大、色彩丰富和美观的特性，具有低选择性，并且对头发可能受到的各种侵蚀因素具有良好的抵抗力，如洗发水、光线、汗水和永久造型。
• 7-phenylpyrazolopyridine compounds
  申请人：——

  公开号：US20040224974A1

  公开（公告）日：2004-11-11

  A compound represented by the formula: 1 [wherein R 1 is methoxy, methylthio, ethyl, etc.; R 5 and R 6 are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R 40 , R 41 and R 42 are C 1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.

  一个由以下公式表示的化合物：1[其中R1是甲氧基，甲硫基，乙基等；R5和R6分别独立地是环丙基甲基，（4-四氢吡喃基）甲基等；而R40、R41和R42中的两个是C1-6烷氧基，剩下的一个是甲氧基甲基等]，其盐或上述化合物的水合物。该化合物对促肾上腺皮质激素释放因子受体有优异的拮抗作用。
• [EN] CATIONIC TETRAHYDROPYRAZOLOPYRIDINES, DYE COMPOSITION COMPRISING SUCH OXIDATION BASES, IMPLEMENTATION PROCESS THEREFOR AND USE THEREOF<br/>[FR] TÉTRAHYDROPYRAZOLOPYRIDINES CATIONIQUES, COMPOSITION DE COLORANT COMPRENANT DE TELLES BASES D'OXYDATION, LEUR PROCÉDÉ DE MISE EN OEUVRE ET LEUR UTILISATION
  申请人：OREAL

  公开号：WO2013087933A1

  公开（公告）日：2013-06-20

  The present invention relates to particular cationic tetrahydropyrazolopyridine compounds of formula (I) below and also to the use thereof for dyeing keratin fibres, in particular human keratin fibres such as the hair. The invention also relates to a dye composition comprising, in a suitable dyeing medium, one or more cationic tetrahydropyrazolopyridines as defined previously. Finally, the invention relates to a dyeing device using the said composition.

  本发明涉及特定的阳离子四氢吡唑吡啶化合物（I）以及其在染色角蛋白纤维，特别是人类角蛋白纤维，如头发中的使用。本发明还涉及一种染料组合物，其中在适当的染料介质中，包含一种或多种如上所定义的阳离子四氢吡唑吡啶。最后，本发明涉及使用该组合物的染色装置。
• 3-aminopyrazolo heterocyclic derivatives, and use for colorimetric
  申请人：Boehringer Mannheim

  公开号：US05457200A1

  公开（公告）日：1995-10-10

  The present invention is concerned with the use of certain 3-aminopyrazolo-heterocyclic compounds for the colorimetric determination of hydrogen peroxide, hydrogen peroxide-forming systems, peroxidase, peroxidate-active substances and electron-rich aromatic compounds. The present invention is also concerned with corresponding processes of determination and with agents appropriate therefor. Furthermore, the present invention is concerned with new 3-aminopyrazolo-heterocyclic compounds.

  本发明涉及使用某些3-氨基吡唑杂环化合物进行过氧化氢、过氧化氢形成体系、过氧化酶、过氧化物活性物质和富电子芳香化合物的比色测定。本发明还涉及相应的测定过程和相应的试剂。此外，本发明还涉及新的3-氨基吡唑杂环化合物。
• Pyrazolo[1,5-a]pyridines and medicines containing the same
  申请人：——

  公开号：US20040122039A1

  公开（公告）日：2004-06-24

  Compounds represented by the general formula: 1 [wherein R 1 represents methoxy, ethyl, methylthio, etc., R 2 , R 3 and R 4 each represent hydrogen, a halogen, etc., R 5 and R 6 each represent —X 5 —X 6 —X 7 (wherein X 5 represents a single bond or —CO—, X 6 represents a single bond, —NR 3a , etc. and X 7 and R 3a each represent hydrogen, C 1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.

  化合物的一般式表示为1，其中R1表示甲氧基，乙基，甲硫基等，R2，R3和R4分别表示氢，卤素等，R5和R6分别表示—X5—X6—X7（其中X5表示单键或—CO—，X6表示单键，—NR3a等，X7和R3a各自表示氢，C1-10烷基等），Ar表示苯基，吡啶基等，其盐和上述化合物的水合物。