The present invention is directed to alkoxy tetrahydro-pyridopyrimidine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
本发明涉及一种作为治疗与
磷酸二酯酶10(PDE10)相关的中枢神经系统疾病的治疗剂的烷氧基四氢
吡啶嘧啶化合物。本发明还涉及利用这类化合物治疗神经学和精神疾病,如精神分裂症、精神病或亨廷顿病,以及与纹状体功能不足或基底神经节功能障碍相关的疾病。