3-(4-甲氧基-苯基)-2-丁醇 | 104174-19-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(4-甲氧基-苯基)-2-丁醇
• 英文名称: 3-p-Anisyl-2-butanol
• 英文别名: 3-(4-Methoxy-phenyl)-2-butanol；3-(4-Methoxyphenyl)butan-2-ol
• CAS: 104174-19-8
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: XAZDONJLDVQBEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(4-甲氧基-苯基)-2-丁醇 在 chromium(VI) oxide 作用下， 以 丙酮 为溶剂， 生成 3-(4-methoxyphenyl)butan-2-one
  参考文献：
  名称：

  The Photolysis of Spiro[2.5]octa-4,7-dien-6-one. Radical Fragmentation in the Photochemistry of 2,5-Cyclohexadienones¹

  摘要：

  DOI：

  10.1021/ja00960a029
• 作为产物：
  描述：

  1-methoxy-4-(1-methoxyprop-1-en-2-yl)benzene 在 氢溴酸 作用下， 以 乙醚 、 水 、 丙酮 为溶剂， 反应 13.5h， 生成 3-(4-甲氧基-苯基)-2-丁醇
  参考文献：
  名称：

  Dynamic Kinetic Asymmetric Amination of Alcohols: From A Mixture of Four Isomers to Diastereo- and Enantiopure α-Branched Amines

  摘要：

  The first dynamic kinetic asymmetric amination of alcohols via borrowing hydrogen methodology is presented. Under the cooperative catalysis by an iridium complex and a chiral phosphoric acid, a-branched alcohols that exist as a mixture of four isomers undergo racemization by two orthogonal mechanisms and are converted to diastereo- and enantiopure amines bearing adjacent stereocenters. The preparation of diastereo- and enantiopure 1,2-amino alcohols is also realized using this catalytic system.

  DOI：

  10.1021/jacs.5b02212

文献信息

• The Reactions of 3-Phenyl-1-butylamine-3-¹⁴C and 3-p-Anisyl-1-butylamine-3-¹⁴C with Nitrous Acid^1,2
  作者：Arthur W. Fort、Robert E. Leary

  DOI：10.1021/ja01495a024

  日期：1960.5

  The diazotization of 3-phenyl-1-butylamine-3-C/sup 14/ in acetic acid gives 3-phenyl-1-butene, 3-phenyl-1-butyl acetate, and diastereoisomeric 3- phenyl-2-butyl acetates. 3-pmixture. The secondary ester products of these reactions show extensive isotope-position rearrangement. The significance of these results is discussed.

  3-苯基-1-丁胺-3-C/sup 14/在乙酸中的重氮化得到3-苯基-1-丁烯、3-苯基-1-丁基乙酸酯和非对映异构的3-苯基-2-丁基乙酸酯。3-混合。这些反应的二级酯产物显示出广泛的同位素位置重排。讨论了这些结果的重要性。
• Dynamic Kinetic Asymmetric Amination of Alcohols: From A Mixture of Four Isomers to Diastereo- and Enantiopure α-Branched Amines
  作者：Zi-Qiang Rong、Yao Zhang、Raymond Hong Bing Chua、Hui-Jie Pan、Yu Zhao

  DOI：10.1021/jacs.5b02212

  日期：2015.4.22

  The first dynamic kinetic asymmetric amination of alcohols via borrowing hydrogen methodology is presented. Under the cooperative catalysis by an iridium complex and a chiral phosphoric acid, a-branched alcohols that exist as a mixture of four isomers undergo racemization by two orthogonal mechanisms and are converted to diastereo- and enantiopure amines bearing adjacent stereocenters. The preparation of diastereo- and enantiopure 1,2-amino alcohols is also realized using this catalytic system.
• The Photolysis of Spiro[2.5]octa-4,7-dien-6-one. Radical Fragmentation in the Photochemistry of 2,5-Cyclohexadienones¹
  作者：David I. Schuster、Carl J. Polowczyk

  DOI：10.1021/ja00960a029

  日期：1966.4