1-(2-Methoxy-phenyl)-2-{4-[(3R,4R)-3-(naphthalen-2-ylmethoxy)-piperidin-4-yl]-phenoxy}-ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-Methoxy-phenyl)-2-{4-[(3R,4R)-3-(naphthalen-2-ylmethoxy)-piperidin-4-yl]-phenoxy}-ethanone
• 英文别名: 1-(2-methoxyphenyl)-2-[4-[(3R,4R)-3-(naphthalen-2-ylmethoxy)piperidin-4-yl]phenoxy]ethanone
• 化学式: C₃₁H₃₁NO₄
• 分子量: 481.591
• InChiKey: AZXIDZJDFFUQLF-JOMNFKBKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  tert-butyl (3R,4R)-3-hydroxy-4-(4-hydroxyphenyl)-piperidine-1-carboxylate 在 盐酸 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 生成 1-(2-Methoxy-phenyl)-2-{4-[(3R,4R)-3-(naphthalen-2-ylmethoxy)-piperidin-4-yl]-phenoxy}-ethanone
  参考文献：
  名称：

  Solid-Phase Synthesis of Aspartic Peptidase Inhibitors:  3-Alkoxy-4-Aryl Piperidines

  摘要：

  [GRAPHICS]The 3-alkoxy-4-aryl piperidines are non-peptide peptidomimetic inhibitors of several aspartic peptidases. The solid-phase functionalization of 3,4-disubstituted piperidine scaffolds using a traceless linker strategy is described. Synthesis of diverse analogues based on this scaffold provides the potential to generate selective inhibitors of this important class of peptidase.

  DOI：

  10.1021/ol016280k

文献信息

• Solid-Phase Synthesis of Aspartic Peptidase Inhibitors:  3-Alkoxy-4-Aryl Piperidines
  作者：Matthew G. Bursavich、Daniel H. Rich

  DOI：10.1021/ol016280k

  日期：2001.8.1

  [GRAPHICS]The 3-alkoxy-4-aryl piperidines are non-peptide peptidomimetic inhibitors of several aspartic peptidases. The solid-phase functionalization of 3,4-disubstituted piperidine scaffolds using a traceless linker strategy is described. Synthesis of diverse analogues based on this scaffold provides the potential to generate selective inhibitors of this important class of peptidase.