Diethyl 2-acetamido-2-[[4-(2-oxobutanoyl)phenyl]methyl]propanedioate | 894413-39-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Diethyl 2-acetamido-2-[[4-(2-oxobutanoyl)phenyl]methyl]propanedioate
• CAS: 894413-39-9
• 化学式: C₂₀H₂₅NO₇
• 分子量: 391.421
• InChiKey: YUZKEGCZSAEYIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Diethyl 2-acetamido-2-[[4-(2-oxobutanoyl)phenyl]methyl]propanedioate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 以81%的产率得到
  参考文献：
  名称：

  COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES

  摘要：

  公开号：

  EP1828224B1
• 作为产物：
  描述：

  4-甲基苯丁酮 在 吡啶 、 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 、 溴 、 sodium ethanolate 、 sodium carbonate 、 戴斯-马丁氧化剂 、 溶剂黄146 、 potassium iodide 作用下， 以 乙醇 、 二氯甲烷 、 二甲基亚砜 、 苯 为溶剂， 生成 Diethyl 2-acetamido-2-[[4-(2-oxobutanoyl)phenyl]methyl]propanedioate
  参考文献：
  名称：

  COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES

  摘要：

  公开号：

  EP1828224B1

文献信息

• WO2008/83346
  申请人：——

  公开号：——

  公开（公告）日：——
• Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides
  申请人：MIAO Zhenwei

  公开号：US20080177027A1

  公开（公告）日：2008-07-24

  Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
• Phenazine and Quinoxaline Substituted Amino Acids and Polypeptides
  申请人：Miao Zhenwei

  公开号：US20100098630A1

  公开（公告）日：2010-04-22

  Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a phenazine or quinoxaline substituent. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides.
• US7332571B2
  申请人：——

  公开号：US7332571B2

  公开（公告）日：2008-02-19
• US7385028B2
  申请人：——

  公开号：US7385028B2

  公开（公告）日：2008-06-10