<4R^*,6S^*,6(1S^*),7R^*>-6-(1-hydroxy-1-methylpropyl)-2,2,7-trimethyl-1,3,5-trioxabicyclo<3.3.0>octane | 140835-88-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: <4R^*,6S^*,6(1S^*),7R^*>-6-(1-hydroxy-1-methylpropyl)-2,2,7-trimethyl-1,3,5-trioxabicyclo<3.3.0>octane
• 英文别名: (2R)-2-[(3aR,5S,6R,6aR)-2,2,6-trimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]butan-2-ol
• CAS: 140835-88-7
• 化学式: C₁₂H₂₂O₄
• 分子量: 230.304
• InChiKey: ZGRUTVAPVMDUQC-KUNJHIDRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (1R*,2S*,3S*,4R*,5S*)-1,2:5,6-diepoxy-4-hydroxy-5-isopropyl-3-methylhexyl N,N-diisopropylcarbamate 在 copper(l) iodide 、 zinc chloride diethyl ether 、 草酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 5.83h， 生成 <4R^*,6S^*,6(1S^*),7R^*>-6-(1-hydroxy-1-methylpropyl)-2,2,7-trimethyl-1,3,5-trioxabicyclo<3.3.0>octane
  参考文献：
  名称：

  Peschke, Bernd; Luessmann, Joerg; Dyrbusch, Michael, Chemische Berichte, 1992, vol. 125, # 6, p. 1421 - 1430

  摘要：

  DOI：

文献信息

• LIPID FORMULATED SINGLE STRANDED RNA
  申请人：Manoharan Muthiah

  公开号：US20130156845A1

  公开（公告）日：2013-06-20

  The present invention provides compositions comprising a nucleic acid lipid particle and an oligomeric compound and uses thereof. In certain embodiments, such compositions are useful as antisense compounds. Certain such antisense compounds are useful as RNase H antisense compounds or as RNAi compounds.

  本发明提供了包含核酸脂质粒子和寡核苷酸化合物的组合物及其用途。在某些实施方式中，这些组合物可用作反义物质。某些这样的反义物质可用作RNase H反义物质或RNAi物质。
• OLIGOMERIC COMPOUNDS AND METHODS
  申请人：Swayze Eric E.

  公开号：US20110313019A1

  公开（公告）日：2011-12-22

  The present invention provides oligomeric compounds and uses thereof. In certain embodiments, such oligomeric compounds are useful as antisense compounds. Certain such antisense compounds are useful as RNase H antisense compounds or as RNAi compounds.

  本发明提供了寡聚物化合物及其用途。在某些实施例中，这些寡聚物化合物可用作反义物质。某些这样的反义物质可用作RNase H反义物质或RNAi化合物。
• 5' AND 2' BIS-SUBSTITUTED NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
  申请人：Swayze Eric E.

  公开号：US20110269821A1

  公开（公告）日：2011-11-03

  The present invention provides modified nucleosides and oligomeric compounds prepared therefrom. More particularyl, the present invention provides modified nucleosides having at least one 5′-substituent and a 2′-O-substituent, oligomeric compounds comprising at least one of these modified nucleosides and methods of using the oligomeric compounds. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
• US8883752B2
  申请人：——

  公开号：US8883752B2

  公开（公告）日：2014-11-11
• US8987435B2
  申请人：——

  公开号：US8987435B2

  公开（公告）日：2015-03-24