2-cyano-N-(2,6-dimethoxypyrimidin-4-yl)-3-[4-(dimethylamino)phenyl]prop-2-enamide | 1197179-82-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-cyano-N-(2,6-dimethoxypyrimidin-4-yl)-3-[4-(dimethylamino)phenyl]prop-2-enamide
• CAS: 1197179-82-0
• 化学式: C₁₈H₁₉N₅O₃
• 分子量: 353.381
• InChiKey: QOANLZVKRJTRIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-cyano-N-(2,6-dimethoxypyrimidin-4-yl)acetamide 、 对二甲氨基苯甲醛 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以76%的产率得到2-cyano-N-(2,6-dimethoxypyrimidin-4-yl)-3-[4-(dimethylamino)phenyl]prop-2-enamide
  参考文献：
  名称：

  5-Cyanoacetylpyrimidines as intermediates for 7-aryl-6-cyanopyrido[2,3-d]pyrimidin-5-ones

  摘要：

  The reactions of N-4- and 5-cyanoacetyl derivates of 4-aminopyrimidines with aromatic aldehydes have yielded the N-(pyrimidin-4-yl)-3-arylacrylamides and the dihydropyrido[2,3-d]pyrimidines, respectively. The first reaction was a Claisen-Schmidt reaction catalysed by base, and the second one proceeded via thermal cyclocondensation. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.070

文献信息

• 5-Cyanoacetylpyrimidines as intermediates for 7-aryl-6-cyanopyrido[2,3-d]pyrimidin-5-ones
  作者：Jairo Quiroga、Jorge Trilleras、Jaime Gálvez、Braulio Insuasty、Rodrigo Abonía、Manuel Nogueras、Justo Cobo

  DOI：10.1016/j.tetlet.2009.08.070

  日期：2009.11

  The reactions of N-4- and 5-cyanoacetyl derivates of 4-aminopyrimidines with aromatic aldehydes have yielded the N-(pyrimidin-4-yl)-3-arylacrylamides and the dihydropyrido[2,3-d]pyrimidines, respectively. The first reaction was a Claisen-Schmidt reaction catalysed by base, and the second one proceeded via thermal cyclocondensation. (C) 2009 Elsevier Ltd. All rights reserved.