| 849659-12-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 849659-12-7
• 化学式: C₄₉H₆₆FN₅O₁₃
• 分子量: 952.087
• InChiKey: OBAGMEUDZFFHIR-HLGUJNHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.07
• 重原子数：
  68.0
• 可旋转键数：
  15.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  222.27
• 氢给体数：
  0.0
• 氢受体数：
  15.0

反应信息

• 作为反应物：
  描述：

  在 甲醇 作用下， 以99%的产率得到11-N-(4-azido-butyl)-6-O-methyl-5-(3-dimethylamine-4-deoxy-6-benzoyl-glucopyranosyl)-2-fluoro-3-oxo-erythronolide A 11,12-carbamate
  参考文献：
  名称：

  Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics

  摘要：

  A series of new triazole-containing ketolides and 2-fluoro-ketolides in which the 5-O-desosamine was replaced by unnatural sugars were synthesized and evaluated against relevant macrolide-sensitive and macrolide-resistant respiratory pathogens. Excellent in vitro antibacterial activities were demonstrated for ketolide analogues having the 6'-OBz-3'-dimethylamino-glucose and 6'-OBz-4'-deoxy-3'-dimethylamino-glucose substituents. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.027
• 作为产物：
  描述：

  聚合甲醛 、 在 三乙酰氧基硼氢化钠 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics

  摘要：

  A series of new triazole-containing ketolides and 2-fluoro-ketolides in which the 5-O-desosamine was replaced by unnatural sugars were synthesized and evaluated against relevant macrolide-sensitive and macrolide-resistant respiratory pathogens. Excellent in vitro antibacterial activities were demonstrated for ketolide analogues having the 6'-OBz-3'-dimethylamino-glucose and 6'-OBz-4'-deoxy-3'-dimethylamino-glucose substituents. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.027