2-(4-Methylphenyl)-5-phenyl-1,3-oxazole-4-sulfonyl chloride | 1432087-93-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-Methylphenyl)-5-phenyl-1,3-oxazole-4-sulfonyl chloride
• 英文别名: 2-(4-methylphenyl)-5-phenyl-1,3-oxazole-4-sulfonyl chloride
• CAS: 1432087-93-8
• 化学式: C₁₆H₁₂ClNO₃S
• 分子量: 333.795
• InChiKey: SZXWWKPNBPOVNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  68.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-Methylphenyl)-5-phenyl-1,3-oxazole-4-sulfonyl chloride 在 氨 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 0.5h， 以81%的产率得到2-(4-Methylphenyl)-5-phenyl-1,3-oxazole-4-sulfonamide
  参考文献：
  名称：

  Amidophenacylating reagents in synthesis of new derivatives of 1,3-oxazole- and 1,3-thiazole-4-sulfonyl chlorides and corresponding sulfonamides

  摘要：

  Derivatives of 4-benzylsulfanyl-1,3-oxazole and 4-benzylsulfanyl-1,3-thiazole were synthesized using available amidophenacylating reagents. By the oxidative chlorination compounds obtained were converted to 1,3-oxazole-4-sulfonyl and 1,3-thiazol-4-sulfonyl chlorides. The latter were used to prepare the corresponding sulfonamides.

  DOI：

  10.1134/s1070363214040148
• 作为产物：
  描述：

  N-(1-chloro-2-oxo-2-phenylethyl)-4-methylbenzamide 在 氯 、 溶剂黄146 、 三乙胺 、 三氯氧磷 作用下， 以 水 、 乙腈 为溶剂， 反应 41.5h， 生成 2-(4-Methylphenyl)-5-phenyl-1,3-oxazole-4-sulfonyl chloride
  参考文献：
  名称：

  Amidophenacylating reagents in synthesis of new derivatives of 1,3-oxazole- and 1,3-thiazole-4-sulfonyl chlorides and corresponding sulfonamides

  摘要：

  Derivatives of 4-benzylsulfanyl-1,3-oxazole and 4-benzylsulfanyl-1,3-thiazole were synthesized using available amidophenacylating reagents. By the oxidative chlorination compounds obtained were converted to 1,3-oxazole-4-sulfonyl and 1,3-thiazol-4-sulfonyl chlorides. The latter were used to prepare the corresponding sulfonamides.

  DOI：

  10.1134/s1070363214040148

文献信息

• Amidophenacylating reagents in synthesis of new derivatives of 1,3-oxazole- and 1,3-thiazole-4-sulfonyl chlorides and corresponding sulfonamides
  作者：A. N. Kornienko、S. G. Pil’o、V. M. Prokopenko、V. S. Brovarets

  DOI：10.1134/s1070363214040148

  日期：2014.4

  Derivatives of 4-benzylsulfanyl-1,3-oxazole and 4-benzylsulfanyl-1,3-thiazole were synthesized using available amidophenacylating reagents. By the oxidative chlorination compounds obtained were converted to 1,3-oxazole-4-sulfonyl and 1,3-thiazol-4-sulfonyl chlorides. The latter were used to prepare the corresponding sulfonamides.