4-(Benzylsulfanyl)-2-(4-methylphenyl)-5-phenyl-1,3-oxazole | 1432284-96-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(Benzylsulfanyl)-2-(4-methylphenyl)-5-phenyl-1,3-oxazole
• 英文别名: 4-benzylsulfanyl-2-(4-methylphenyl)-5-phenyl-1,3-oxazole
• CAS: 1432284-96-2
• 化学式: C₂₃H₁₉NOS
• 分子量: 357.476
• InChiKey: IHEUFRRNFNYJOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  51.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(Benzylsulfanyl)-2-(4-methylphenyl)-5-phenyl-1,3-oxazole 在 氯 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 12.5h， 以72%的产率得到2-(4-Methylphenyl)-5-phenyl-1,3-oxazole-4-sulfonyl chloride
  参考文献：
  名称：

  Amidophenacylating reagents in synthesis of new derivatives of 1,3-oxazole- and 1,3-thiazole-4-sulfonyl chlorides and corresponding sulfonamides

  摘要：

  Derivatives of 4-benzylsulfanyl-1,3-oxazole and 4-benzylsulfanyl-1,3-thiazole were synthesized using available amidophenacylating reagents. By the oxidative chlorination compounds obtained were converted to 1,3-oxazole-4-sulfonyl and 1,3-thiazol-4-sulfonyl chlorides. The latter were used to prepare the corresponding sulfonamides.

  DOI：

  10.1134/s1070363214040148
• 作为产物：
  描述：

  N-[1-(benzylsulfanyl)-2-oxo-2-phenylethyl]-4-methylbenzamide 在 三氯氧磷 作用下， 反应 17.0h， 以70%的产率得到4-(Benzylsulfanyl)-2-(4-methylphenyl)-5-phenyl-1,3-oxazole
  参考文献：
  名称：

  Amidophenacylating reagents in synthesis of new derivatives of 1,3-oxazole- and 1,3-thiazole-4-sulfonyl chlorides and corresponding sulfonamides

  摘要：

  Derivatives of 4-benzylsulfanyl-1,3-oxazole and 4-benzylsulfanyl-1,3-thiazole were synthesized using available amidophenacylating reagents. By the oxidative chlorination compounds obtained were converted to 1,3-oxazole-4-sulfonyl and 1,3-thiazol-4-sulfonyl chlorides. The latter were used to prepare the corresponding sulfonamides.

  DOI：

  10.1134/s1070363214040148

文献信息

• Amidophenacylating reagents in synthesis of new derivatives of 1,3-oxazole- and 1,3-thiazole-4-sulfonyl chlorides and corresponding sulfonamides
  作者：A. N. Kornienko、S. G. Pil’o、V. M. Prokopenko、V. S. Brovarets

  DOI：10.1134/s1070363214040148

  日期：2014.4

  Derivatives of 4-benzylsulfanyl-1,3-oxazole and 4-benzylsulfanyl-1,3-thiazole were synthesized using available amidophenacylating reagents. By the oxidative chlorination compounds obtained were converted to 1,3-oxazole-4-sulfonyl and 1,3-thiazol-4-sulfonyl chlorides. The latter were used to prepare the corresponding sulfonamides.