| 149805-65-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 149805-65-2
• 化学式: C₂₉H₅₂O₈Si₃
• 分子量: 612.984
• InChiKey: UQYVIPIUAUGEPP-ZLZQRCJISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  40.0
• 可旋转键数：
  15.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  96.73
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  在 氢气 作用下， 生成
  参考文献：
  名称：

  Synthesis and antibacterial properties of β-diketone acrylate bioisosteres of pseudomonic acid A

  摘要：

  A series of beta-diketone acrylate bioisosteres 4 of pseudomonic acid A 1 have been synthesized and evaluated for their ability to inhibit bacterial isoleucyl-tRNA synthetase and act as antibacterial agents. A number of analogues have excellent antibacterial activity. Selected examples were shown to afford good blood levels and to be effective in a murine infection model. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00296-6
• 作为产物：
  描述：

  <(2S,3R,4R,5S)-3,4-bis<(trimethylsilyl)oxy>-5-<(2S,3S,4S,5S)-2,3-epoxy-5-<(trimethylsilyl)oxy>-4-methylhexyl>tetrahydropyran-2-yl>acetone 在 manganese(IV) oxide 、 lithium diisopropyl amide 作用下， 以 苯 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and antibacterial properties of β-diketone acrylate bioisosteres of pseudomonic acid A

  摘要：

  A series of beta-diketone acrylate bioisosteres 4 of pseudomonic acid A 1 have been synthesized and evaluated for their ability to inhibit bacterial isoleucyl-tRNA synthetase and act as antibacterial agents. A number of analogues have excellent antibacterial activity. Selected examples were shown to afford good blood levels and to be effective in a murine infection model. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00296-6