(R)-5-chloro-2-[3-hydroxy-3-(3-hydroxyphenyl)propyl]benzoic acid methyl ester | 177747-96-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (R)-5-chloro-2-[3-hydroxy-3-(3-hydroxyphenyl)propyl]benzoic acid methyl ester
• 英文别名: methyl 5-chloro-2-[(3R)-3-hydroxy-3-(3-hydroxyphenyl)propyl]benzoate
• CAS: 177747-96-5
• 化学式: C₁₇H₁₇ClO₄
• 分子量: 320.773
• InChiKey: ZIIFOSPZUAEBBW-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-5-chloro-2-[3-hydroxy-3-(3-hydroxyphenyl)propyl]benzoic acid methyl ester 在 乙基溴化镁 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.92h， 生成 5-chloro-2-[(3R)-3-[3-[(7-chloroquinolin-2-yl)methoxy]phenyl]-3-hydroxypropyl]-N,N-dimethylbenzamide
  参考文献：
  名称：

  Practical Route to a New Class of LTD₄ Receptor Antagonists

  摘要：

  A general approach to the synthesis of a new class of LTD(4) antagonists is presented. The key diarylpropane framework was prepared by Claisen-Schmidt condensation and selective reduction of the enone. Depending on the bridge to the 7-chloroquinaldine moiety, alkylation or Heck coupling methodology was developed. The chiral sulfides were introduced by asymmetric reduction of the diarylpropanone intermediates and subsequent inversion of the chiral center.

  DOI：

  10.1021/jo952103j
• 作为产物：
  描述：

  5-chloro-2-[3-(3-hydroxyphenyl)-3-oxopropyl]benzoic acid 在 dimethyl sulfide borane 、 硫酸 、 (S)-2-甲基-CBS-恶唑硼烷 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 36.0h， 生成 (R)-5-chloro-2-[3-hydroxy-3-(3-hydroxyphenyl)propyl]benzoic acid methyl ester
  参考文献：
  名称：

  Practical Route to a New Class of LTD₄ Receptor Antagonists

  摘要：

  A general approach to the synthesis of a new class of LTD(4) antagonists is presented. The key diarylpropane framework was prepared by Claisen-Schmidt condensation and selective reduction of the enone. Depending on the bridge to the 7-chloroquinaldine moiety, alkylation or Heck coupling methodology was developed. The chiral sulfides were introduced by asymmetric reduction of the diarylpropanone intermediates and subsequent inversion of the chiral center.

  DOI：

  10.1021/jo952103j

文献信息

• Practical Route to a New Class of LTD₄ Receptor Antagonists
  作者：Robert D. Larsen、Edward G. Corley、Anthony O. King、James D. Carroll、Paul Davis、Thomas R. Verhoeven、Paul J. Reider、Marc Labelle、Jacques Y. Gauthier、Yi Bin Xiang、Robert J. Zamboni

  DOI：10.1021/jo952103j

  日期：1996.1.1

  A general approach to the synthesis of a new class of LTD(4) antagonists is presented. The key diarylpropane framework was prepared by Claisen-Schmidt condensation and selective reduction of the enone. Depending on the bridge to the 7-chloroquinaldine moiety, alkylation or Heck coupling methodology was developed. The chiral sulfides were introduced by asymmetric reduction of the diarylpropanone intermediates and subsequent inversion of the chiral center.