5-(2-Methylquinolin-4-yl)-1,3,4-oxadiazole-2(3H)-thione | 90074-18-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-(2-Methylquinolin-4-yl)-1,3,4-oxadiazole-2(3H)-thione
• 英文别名: 5-(2-methylquinolin-4-yl)-3H-1,3,4-oxadiazole-2-thione
• CAS: 90074-18-3
• 化学式: C₁₂H₉N₃OS
• mdl: MFCD11174880
• 分子量: 243.289
• InChiKey: SFEVHWNSYMTSQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(2-Methylquinolin-4-yl)-1,3,4-oxadiazole-2(3H)-thione 、 alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以71.8%的产率得到2-Ethylsulfanyl-5-(2-methylquinolin-4-yl)-1,3,4-oxadiazole
  参考文献：
  名称：

  Synthesis of Some New Antimicrobial Thiadiazolyl and Oxadiazolyl Quinoline Derivatives

  摘要：

  Two series of substituted thiadiazolyl and oxadiazolylquinolines (3a-h, 4a-h, 7a-f, 8a-f and 9) were synthesized and screened for their antimicrobial activity. Some of the tested compounds showed promising activity. Compound 4b exhibited bactericidal activity against S. aureus at 31.25 mu g/ml. While compound 8a showed distinct antifungal activity against C. albicans (MIC at 31.25 mu g/ml). The detailed synthesis, spectroscopic and biological data are reported.

  DOI：

  10.1007/s00044-005-0138-7
• 作为产物：
  描述：

  二硫化碳 、 2-甲基喹啉-4-羧酸肼 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 以82.3%的产率得到5-(2-Methylquinolin-4-yl)-1,3,4-oxadiazole-2(3H)-thione
  参考文献：
  名称：

  Synthesis of Some New Antimicrobial Thiadiazolyl and Oxadiazolyl Quinoline Derivatives

  摘要：

  Two series of substituted thiadiazolyl and oxadiazolylquinolines (3a-h, 4a-h, 7a-f, 8a-f and 9) were synthesized and screened for their antimicrobial activity. Some of the tested compounds showed promising activity. Compound 4b exhibited bactericidal activity against S. aureus at 31.25 mu g/ml. While compound 8a showed distinct antifungal activity against C. albicans (MIC at 31.25 mu g/ml). The detailed synthesis, spectroscopic and biological data are reported.

  DOI：

  10.1007/s00044-005-0138-7

文献信息

• Synthesis of Some New Antimicrobial Thiadiazolyl and Oxadiazolyl Quinoline Derivatives
  作者：O.H. Rizk、M.A. Mahran、S.M. El-Khawass、S.A. Shams El-Dine、El-Sebai A. Ibrahim

  DOI：10.1007/s00044-005-0138-7

  日期：2005.7

  Two series of substituted thiadiazolyl and oxadiazolylquinolines (3a-h, 4a-h, 7a-f, 8a-f and 9) were synthesized and screened for their antimicrobial activity. Some of the tested compounds showed promising activity. Compound 4b exhibited bactericidal activity against S. aureus at 31.25 mu g/ml. While compound 8a showed distinct antifungal activity against C. albicans (MIC at 31.25 mu g/ml). The detailed synthesis, spectroscopic and biological data are reported.