(2R)-3-(4-cyanophenyl)-N-(3,5-dichlorophenyl)-2-methyl-2-(5-oxo-2-sulfanylideneimidazolidin-1-yl)propanamide | 835917-15-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-3-(4-cyanophenyl)-N-(3,5-dichlorophenyl)-2-methyl-2-(5-oxo-2-sulfanylideneimidazolidin-1-yl)propanamide
• CAS: 835917-15-2
• 化学式: C₂₀H₁₆Cl₂N₄O₂S
• 分子量: 447.345
• InChiKey: PRINKCBGIYROAX-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2R)-3-(4-cyanophenyl)-N-(3,5-dichlorophenyl)-2-methyl-2-(5-oxo-2-sulfanylideneimidazolidin-1-yl)propanamide 在 三甲基氯硅烷 、 Celite 、 N,N-二异丙基乙胺 、 sodium iodide 、 copper(l) chloride 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 甲苯 、 乙腈 为溶剂， 反应 0.83h， 生成 (R)-3-(4-cyanobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-imidazo[1,2-a]-imidazol-2-one
  参考文献：
  名称：

  A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins

  摘要：

  An efficient and chromatography-free approach for synthesis of a new class of LFA- I inhibitor was developed. A copper(I) chloride-promoted intramolecular cyclization of thiohydantoins 7a-b serves as a key step to highly functionalized bicyclic guanidines 5a-b, that were subsequently converted to H-imidazol[l,2-a]imidazol-2-one LFA-1 inhibitors. This process has been successfully implemented in the pilot plant to produce multikilogram quantities of LFA-1 inhibitors such as la-b. (C) 2004 Elsevier Ltd. All ri.-hts reserved

  DOI：

  10.1016/j.tetlet.2004.11.065
• 作为产物：
  描述：

  (2R,5R)-3-(3,5-二氯苯基)-2-异丙基-5-甲基-1-(2,2,2-三氯乙酰基)-咪唑烷-4-酮 在 sodium hydroxide 、 三甲基乙酰氯 、 苄基三甲基氢氧化铵 、 对甲苯磺酸 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 为溶剂， 生成 (2R)-3-(4-cyanophenyl)-N-(3,5-dichlorophenyl)-2-methyl-2-(5-oxo-2-sulfanylideneimidazolidin-1-yl)propanamide
  参考文献：
  名称：

  A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins

  摘要：

  An efficient and chromatography-free approach for synthesis of a new class of LFA- I inhibitor was developed. A copper(I) chloride-promoted intramolecular cyclization of thiohydantoins 7a-b serves as a key step to highly functionalized bicyclic guanidines 5a-b, that were subsequently converted to H-imidazol[l,2-a]imidazol-2-one LFA-1 inhibitors. This process has been successfully implemented in the pilot plant to produce multikilogram quantities of LFA-1 inhibitors such as la-b. (C) 2004 Elsevier Ltd. All ri.-hts reserved

  DOI：

  10.1016/j.tetlet.2004.11.065