二甲基哌啶-2,5-二羧酸 | 2207-52-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 二甲基哌啶-2,5-二羧酸
• 中文别名: 哌啶-2,5-二甲酸二甲酯
• 英文名称: Piperidin-2,5-dicarbonsaeure-dimethylester
• 英文别名: Dimethyl piperidine-2,5-dicarboxylate
• CAS: 2207-52-5
• 化学式: C₉H₁₅NO₄
• 分子量: 201.222
• InChiKey: SGOAVLHEGKCEHK-UHFFFAOYSA-N

物化性质

• 沸点：
  104-106 °C(Press: 0.4 Torr)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  二甲基哌啶-2,5-二羧酸 在 盐酸 、 水杨醛 、 溶剂黄146 、 三氟乙酸酐 、 sodium nitrite 作用下， 以 四氢呋喃 、 水 、 间二甲苯 为溶剂， 反应 30.0h， 生成 2-(piperidin-1-ylcarbonyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-6-carboxylic acid methyl ester
  参考文献：
  名称：

  Preparation of differentiated diamides of 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2,6- and −3,6-dicarboxylic acids suitable for parallel synthesis

  摘要：

  1,3-Dipolar cycloaddition of a bicyclic sydnone to a propargylic acid amide affords 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2,6- and -3,6-dicarboxylic acid monoamides which are further converted to corresponding differentiated diamides.

  DOI：

  10.1007/s10593-011-0840-y
• 作为产物：
  描述：

  2,5-吡啶-二羧酸二甲酯 生成 二甲基哌啶-2,5-二羧酸
  参考文献：
  名称：

  Bis-aza-bicyclic anxiolytic agents

  摘要：

  抗焦虑剂是拥有手性或非手性吡啶[1,2-a]吡嗪衍生物，其化学式为##STR1##其中x为N或CH，Y代表某些嘧唑啉、三唑啉、四唑啉或环状亚酰胺基团；以及其中间体。

  公开号：

  US05122525A1

文献信息

• Pyrrolidine derivatives
  申请人：——

  公开号：US20020040146A1

  公开（公告）日：2002-04-04

  The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction.

  本发明涉及吡咯烷衍生物，其作为金属蛋白酶抑制剂，例如锌蛋白酶，在治疗与血管收缩相关的疾病状态中具有有效性。
• MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME
  申请人：TABATA Masayoshi

  公开号：US20110224343A1

  公开（公告）日：2011-09-15

  The present invention provides a modifier for aromatic polyesters which enhances the melt fluidity of aromatic polyesters without a significant decrease in the heat resistance of the aromatic polyesters, and an aromatic polyester resin composition including the modifier for aromatic polyesters. The present invention relates to a modifier for aromatic polyesters comprising polyhydric phenol residues and residues of aromatic polycarboxylic acid, acid halide or acid anhydride thereof, and the modifier comprises a material having a structure composed of a first residue selected from the group consisting of divalent residues represented by Formula (I): —Ar—W 1 x —Ar— and by Formula (II): —Ar—, the first residues being bonded to two identical or different second residues selected from the group consisting of monovalent residues represented by Formula (III): and monovalent residues represented by Formula (IV): —O—C(O)—R 7 —.

  本发明提供了一种用于芳香族聚酯的改性剂，可以增强芳香族聚酯的熔融流动性，而不明显降低芳香族聚酯的耐热性，以及包括该改性剂的芳香族聚酯树脂组合物。本发明涉及一种用于芳香族聚酯的改性剂，包括多羟基酚残基和芳香族多羧酸、酸卤或其酸酐残基，该改性剂包括具有以下结构的材料：第一残基，选择自由式(I)所代表的二价残基：—Ar—W1x—Ar—和自由式(II)所代表的：—Ar—，第一残基与选择自由式(III)所代表的单价残基：和自由式(IV)所代表的单价残基：—O—C(O)—R7—的两个相同或不同的第二残基结合。
• [EN] PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS<br/>[FR] DERIVES DE PYRROLIDINE UTILISES EN TANT QU'INHIBITEURS DE METALLOPROTEASE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002008185A1

  公开（公告）日：2002-01-31

  The present invention relates to compounds of formula (I) wherein R?1, R2, R3, R4, R5, R6¿, Y, n, m, o. p and q are as defined in the description and the claims and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.

  本发明涉及公式（I）的化合物，其中R？1，R2，R3，R4，R5，R6¿，Y，n，m，o。 p和q如描述和要求中所定义的二聚体形式和/或药学上可接受的酯和/或盐。这些化合物可用作金属蛋白酶抑制剂，例如锌蛋白酶，特别是锌水解酶，并且有效治疗与血管收缩增加有关的疾病状态。
• AROMATIC POLYESTER
  申请人：Muroran Institute of Technology

  公开号：EP2479203A1

  公开（公告）日：2012-07-25

  The present invention provides an aromatic polyester which is substantially free from the occurrence of coloration and retains significantly high transparency even after being thermally processed at high temperature and which has high flowability. The aromatic polyester contains a polyhydric phenol residue and a residue of any one of aromatic polycarboxylic acid, halide thereof, and anhydride thereof, and terminals of the aromatic polyester have a structure represented by the formula -C(O)-R. The aromatic polyester has an end-capping rate of 90% or higher and a weight average molecular weight (Mw) ranging from 3,000 to 1,000,000.

  本发明提供了一种芳香族聚酯，该聚酯基本上不会发生着色，即使在高温热加工后仍能保持明显的高透明度，并且具有高流动性。芳香族聚酯含有多羟基苯酚残留物和芳香族多羧酸、其卤化物和其酸酐中任意一种的残留物，芳香族聚酯的端基具有式 -C(O)-R 所代表的结构。芳香族聚酯的端盖率为 90% 或更高，重量平均分子量（Mw）为 3,000 至 1,000,000 之间。
• BTK inhibitors
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US10130630B2

  公开（公告）日：2018-11-20

  The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.

  本发明提供了根据式（I）的布鲁顿酪氨酸激酶（Btk）抑制剂化合物，或其药学上可接受的盐或立体异构体，或包含这些化合物的药物组合物，以及它们在治疗中的用途。特别是，本发明涉及式（I）Btk抑制剂化合物在治疗Btk介导的疾病中的用途。