{3-[4-(tert-Butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone | 476686-88-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: {3-[4-(tert-Butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone
• CAS: 476686-88-1
• 化学式: C₃₂H₃₅NO₂Si
• 分子量: 493.721
• InChiKey: ADGXAPDPMKDOHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.21
• 重原子数：
  36.0
• 可旋转键数：
  10.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  39.19
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  {3-[4-(tert-Butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone 在 potassium permanganate 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 4-[3-(3-Pyridylcarbonyl)phenyl]butyric Acid
  参考文献：
  名称：

  Novel Agents Combining Platelet Activating Factor (PAF) Receptor Antagonist with Thromboxane Synthase Inhibitor (TxSI)

  摘要：

  Compounds 1 or 2 which possess dual-acting PAF antagonist/TxSI in a previous paper were modified and evaluated for the dual-acting activity. It was found that several compounds were potent dual-acting PAF antagonist/TxSI in and ex vivo. 6-(2-Chlorophenyl)-3-[4-[(E /Z)-6-ethoxvcarbonyl-1-(3-pyridyl)-1-hexenyl]phenylmethyl]-8,11-dimethyl-2,3.4,5-tetrahydro-8H-pyrido[4',3': 4.5]thieno[3.2-f][1,2,4]triazolo[4,3-a][1.4]diazepine (12) is excellent orally dual-acting PAF antagonist/TxSI. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00005-7
• 作为产物：
  描述：

  {3-[4-(tert-Butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanol 在 manganese(IV) oxide 作用下， 以 二氯甲烷 为溶剂， 以86%的产率得到{3-[4-(tert-Butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone
  参考文献：
  名称：

  Novel Agents Combining Platelet Activating Factor (PAF) Receptor Antagonist with Thromboxane Synthase Inhibitor (TxSI)

  摘要：

  Compounds 1 or 2 which possess dual-acting PAF antagonist/TxSI in a previous paper were modified and evaluated for the dual-acting activity. It was found that several compounds were potent dual-acting PAF antagonist/TxSI in and ex vivo. 6-(2-Chlorophenyl)-3-[4-[(E /Z)-6-ethoxvcarbonyl-1-(3-pyridyl)-1-hexenyl]phenylmethyl]-8,11-dimethyl-2,3.4,5-tetrahydro-8H-pyrido[4',3': 4.5]thieno[3.2-f][1,2,4]triazolo[4,3-a][1.4]diazepine (12) is excellent orally dual-acting PAF antagonist/TxSI. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00005-7