2-(2-chloro-5-(trifluoromethyl)phenoxy)-4-(trifluoromethyl)thiazole-5-carbonyl chloride | 928032-98-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-chloro-5-(trifluoromethyl)phenoxy)-4-(trifluoromethyl)thiazole-5-carbonyl chloride
• CAS: 928032-98-8
• 化学式: C₁₂H₃Cl₂F₆NO₂S
• 分子量: 410.124
• InChiKey: HYHASDRHGAORDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.01
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  39.19
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-(2-chloro-5-(trifluoromethyl)phenoxy)-4-(trifluoromethyl)thiazole-5-carbonyl chloride 、 二乙胺 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 0.17h， 以92%的产率得到2-(2-chloro-5-(trifluoromethyl)phenoxy)-N,N-diethyl-4-(trifluoromethyl)thiazole-5-carboxamide
  参考文献：
  名称：

  Synthesis and biological activity of novel 2-(3-trifluoromethylphenoxy)-4-trifluoromethylthiazole-5-carboxamide derivatives

  摘要：

  Novel 2-(3-trifluoromethylphenoxy)-4-trifluoromethylthiazole-5-carboxanlides were designed and synthesized utilizing ethyl 3-amino-4,4,4-trifluoro-2-butenoate as a starting material via six steps. Subsequently, their biological activities were evaluated in the greenhouse. Results indicated that several compounds have some insecticidal or fungicidal activity at 600 g ai/ha and 300 g ai/ha, respectively. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2006.02.010
• 作为产物：
  描述：

  2-(2-chloro-5-(trifluoromethyl)phenoxy)-4-(trifluoromethyl)thiazole-5-carboxylic acid 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 反应 2.0h， 生成 2-(2-chloro-5-(trifluoromethyl)phenoxy)-4-(trifluoromethyl)thiazole-5-carbonyl chloride
  参考文献：
  名称：

  Synthesis and biological activity of novel 2-(3-trifluoromethylphenoxy)-4-trifluoromethylthiazole-5-carboxamide derivatives

  摘要：

  Novel 2-(3-trifluoromethylphenoxy)-4-trifluoromethylthiazole-5-carboxanlides were designed and synthesized utilizing ethyl 3-amino-4,4,4-trifluoro-2-butenoate as a starting material via six steps. Subsequently, their biological activities were evaluated in the greenhouse. Results indicated that several compounds have some insecticidal or fungicidal activity at 600 g ai/ha and 300 g ai/ha, respectively. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2006.02.010