Cyclohexyl-(6,7-dimethoxy-quinolin-3-yl)-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Cyclohexyl-(6,7-dimethoxy-quinolin-3-yl)-amine
• 英文别名: N-cyclohexyl-6,7-dimethoxyquinolin-3-amine
• 化学式: C₁₇H₂₂N₂O₂
• 分子量: 286.374
• InChiKey: LYYMGYKLKOJMPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  43.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  环己酮 、 3-amino-6,7-dimethoxyquinoline 在 sodium cyanoborohydride 作用下， 生成 Cyclohexyl-(6,7-dimethoxy-quinolin-3-yl)-amine
  参考文献：
  名称：

  Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR Exploration and Effective Bioisosteric Replacement of a phenyl substituent

  摘要：

  Novel substituted 2-anilino- and 2-cycloalkylaminoquinoxalines have been found to be useful and selective inhibitors of PDGF-R autophosphorylation. Replacement of an anilino-substituent with substituted cyclohexylamino- or norbornylamino substituents led to significant improvements in the pharmacokinetic profile of these analogues. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00654-1

文献信息

• Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR Exploration and Effective Bioisosteric Replacement of a phenyl substituent
  作者：Michael R. Myers、Wei He、Barbara Hanney、Natalie Setzer、Martin P. Maguire、Allison Zulli、Glenda Bilder、Helen Galzcinski、Dilip Amin、Saul Needle、Alfred P. Spada

  DOI：10.1016/s0960-894x(03)00654-1

  日期：2003.9

  Novel substituted 2-anilino- and 2-cycloalkylaminoquinoxalines have been found to be useful and selective inhibitors of PDGF-R autophosphorylation. Replacement of an anilino-substituent with substituted cyclohexylamino- or norbornylamino substituents led to significant improvements in the pharmacokinetic profile of these analogues. (C) 2003 Elsevier Ltd. All rights reserved.