3-(3,5-dimethylphenyl)-1-phenylquinolin-4(1H)-one | 1258792-60-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(3,5-dimethylphenyl)-1-phenylquinolin-4(1H)-one
• 英文别名: 3-(3,5-Dimethylphenyl)-1-phenylquinolin-4-one；3-(3,5-dimethylphenyl)-1-phenylquinolin-4-one
• CAS: 1258792-60-7
• 化学式: C₂₃H₁₉NO
• 分子量: 325.41
• InChiKey: JSPHXGGLRUCWOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(2-Bromophenyl)-2-(3,5-dimethylphenyl)ethanone 在 三氯氧磷 作用下， 以 二甲基亚砜 为溶剂， 反应 8.5h， 生成 3-(3,5-dimethylphenyl)-1-phenylquinolin-4(1H)-one
  参考文献：
  名称：

  Metal-Free Intramolecular Amination: One-Pot Tandem Synthesis of 3-Substituted 4-Quinolones

  摘要：

  3-Substituted 4-quinolones were synthesized using a one-pot metal-free strategy in moderate to quantitative yields. Carried out in dimethylsulfoxide (DMSO) via a sequential addition of materials, the methodology is tolerant of a wide range of functional groups and applicable to library synthesis.

  DOI：

  10.1021/co1000103

文献信息

• Metal-Free Intramolecular Amination: One-Pot Tandem Synthesis of 3-Substituted 4-Quinolones
  作者：Qi-Lun Liu、Qiu-Lian Li、Xiang-Dong Fei、Yong-Ming Zhu

  DOI：10.1021/co1000103

  日期：2011.1.10

  3-Substituted 4-quinolones were synthesized using a one-pot metal-free strategy in moderate to quantitative yields. Carried out in dimethylsulfoxide (DMSO) via a sequential addition of materials, the methodology is tolerant of a wide range of functional groups and applicable to library synthesis.