oxacyclotetradecane | 295-19-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: oxacyclotetradecane
• CAS: 295-19-2
• 化学式: C₁₃H₂₆O
• 分子量: 198.349
• InChiKey: VJJAADZVEKOPSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-氧杂环十四烷-2-酮 在 劳森试剂 、 偶氮二异丁腈 、 三正丁基氢锡 、 三乙基硼氢化锂 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 108.0h， 生成 oxacyclotetradecane
  参考文献：
  名称：

  14元大环醚的合成

  摘要：

  作为正在进行的大环化合物化学研究的一部分，合成了具有各种甲基取代模式的14元大环醚。这些大环醚的制备涉及环状酮的Baeyer-Villiger环膨胀或羟基酸的大内酯化以产生内酯。内酯羰基可通过转化成中间体的硫代内酯而除去，该中间体是通过与Lawesson试剂反应并还原而获得的，或者是通过使用三氟化硼醚化物介导的硼氢化钠反应直接还原而得到的。

  DOI：

  10.1016/s0040-4020(99)00846-7

文献信息

• Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
  申请人：Pulaski P. Steven

  公开号：US20050014729A1

  公开（公告）日：2005-01-20

  A method for preventing or treating dermatological disorders and dermatological disorder-related complications in a subject involves a monotherapy with a Cox-2 inhibitor or a combination therapy with a Cox-2 inhibitor and a dermatological treatment agent. Also described are therapeutic compositions comprising a Cox-2 inhibitor and a dermatological treatment agent. Pharmaceutical compositions and kits for implementing the present method are also described.

  一种预防或治疗受试者的皮肤病和与皮肤病相关并发症的方法涉及使用Cox-2抑制剂进行单独治疗或与Cox-2抑制剂和皮肤治疗剂的联合治疗。还描述了包含Cox-2抑制剂和皮肤治疗剂的治疗组合物。还描述了用于实施本方法的药物组合物和工具包。
• Two-component industrial maintenance resin coating systems and compositions and coating processes using them
  申请人：CELANESE CORPORATION

  公开号：EP0024915A1

  公开（公告）日：1981-03-11

  The present invention is directed to a two-component industrial maintenance coating system. The first component comprises a polyamine terminated epoxy resin which is end capped with specifically defined monoepoxides. A co-solvent is optionally employed in the first component where the end capped adduct is a solid at room temperature. The second component comprises a low molecular weight polyepoxide resin crosslinker and optionally a diluent when the epoxy crosslinker is very viscous or solid at room temperature. Before the two components are mixed together the end capped adduct is converted to its water soluble or water dispersable salt form by reaction with a volatile acid to achieve a certain degree of salting. When the two components are mixed together the epoxide resin crosslinker is microemulsified. The composition which results upon mixing the components is curable at room temperature and exhibits an excellent balance of chemical and physical properties.

  本发明涉及一种双组分工业维护涂料体系。第一组份由端封有特定单环氧化物的多胺端封环氧树脂组成。第一组份中可选择使用助溶剂，其中端封端加合物在室温下为固体。第二组份包括低分子量的聚环氧树脂交联剂，当环氧树脂交联剂在室温下非常粘稠或呈固态时，可选择使用稀释剂。在将两种成分混合在一起之前，通过与挥发性酸反应，将端封加成物转化为水溶性或水分散性盐形式，以达到一定的盐化程度。当两种成分混合在一起时，环氧树脂交联剂被微乳化。混合后的组合物可在室温下固化，并具有出色的化学和物理性能平衡。
• Novolac based epoxy resin curing agents for use in aqueous systems
  申请人：INTEREZ, Inc. (a Georgia corporation)

  公开号：EP0175588A2

  公开（公告）日：1986-03-26

  The instant invention is an epoxy resin curing agent based upon an epoxy novolac containing, on the average, between about and 7.5 epoxy groups per molecule, in which substantially all of the epoxide groups are reacted with a polyamine wherein each primary amine hydrogen in the resulting reaction product is further reacted with a monoepoxide or a monocarboxylic acid. The resulting epoxy resin curing agent may be used in a water based system for curing epoxide resins. The curing agent is rendered water soluble or water dispersible by salting with a conventional volatile monocarboxylic acid such as acetic, formic or propionic acid.

  本发明是一种环氧树脂固化剂，基于平均每分子含有约至 7.5 个环氧基团的环氧酚醛， 其中基本上所有的环氧基团都与多胺反应，而反应产物中的每个伯胺氢进一步与一元环氧 物或一元羧酸反应。生成的环氧树脂固化剂可用于固化环氧树脂的水基体系中。通过与常规挥发性单羧酸（如乙酸、甲酸或丙酸）进行盐析，可使固化剂具有水溶性或水分散性。
• Novolac based epoxy resin curing agents for use in solvent
  申请人：INTEREZ, Inc. (a Georgia corporation)

  公开号：EP0175589A2

  公开（公告）日：1986-03-26

  The instant invention is an epoxy resin curing agent based upon an epoxy novolac containing, on the average, between about 3 and about 7.5 epoxy groups per molecule, in which substantially all of the epoxide groups are reacted with a polyamine wherein each primary amine hydrogen in the resulting reaction product is further reacted with a monoepoxide. The resulting epoxy resin curing agent may be used in a solvent based system to cure epoxy resins under low temperature curing conditions.

  本发明是一种环氧树脂固化剂，基于平均每个分子含有约 3 至约 7.5 个环氧基团的环氧酚醛，其中基本上所有的环氧基团都与多胺反应，在反应生成物中的每个伯胺氢进一步与单环氧化物反应。 所生成的环氧树脂固化剂可用于溶剂型体系，在低温固化条件下固化环氧树脂。
• Lubricating composition containing a detergent
  申请人：The Lubrizol Corporation

  公开号：US10077413B2

  公开（公告）日：2018-09-18

  The invention provides a process to prepare a detergent in the presence of a polyether compound. The invention further provides for a lubricating composition containing the detergent. The invention further relates to the use of the lubricating composition in a mechanical device such as an internal combustion engine.

  本发明提供了一种在聚醚化合物存在下制备洗涤剂的工艺。本发明还提供了一种含有洗涤剂的润滑组合物。本发明还涉及润滑组合物在机械设备（如内燃机）中的使用。