Improved methods for the reductive alkylation of methoxybenzoic acids and esters: applications to the synthesis of bicyclic ketones
作者:Robert J. Hamilton、Lewis N. Mander、S.Paul Sethi
DOI:10.1016/s0040-4020(01)90577-0
日期:1986.1
employed to introduce the elements of a butanone or pentanone side-chain as a prelude to adding a fused six-membered ring, thereby completing the preparation of several analogues of the Wieland-Miescher ketone 4a in which the angular substituent was oxygenated.
Studies on reductive alkylation: Synthesis of Wieland-Miescher ketone analogues bearing an oxygenated angular substituent
作者:L.N. Mander、R.J. Hamilton
DOI:10.1016/s0040-4039(01)82080-3
日期:1981.1
Wieland-Miescheranalogues 2a and 2b have been prepared in good yield by a sequence utilising reductive alkylation of the dihydro aromatic ester enolate 7d, which functions as a synthetic equivalent of the dioxo ester 5 anion; these analogues are envisaged as intermediates in a projected synthesis of bruceantin.
Practical and versatile syntheses of angular hydroxymethylated decalones
作者:Young-Ger Suh、Hwa-Soon Kim、P. Raja kumar、Nam-Song Choi、Jae-Kyung Jung
DOI:10.1016/s0040-4020(98)00965-x
日期:1998.12
The practical and versatile syntheses of angular hydroxymethylated decalones as potential syntheticintermediates for terpenoids are described. Particularly angular hydroxymethylated bicyclodecanedione 1 has been synthesized in 45 % overall yield from methyl 2,6-dimethoxy-1,4-dihydrobenzoate via six step sequence.