methyl isohaematommate | 64400-53-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl isohaematommate
• 英文别名: 3-formyl-4,6-dihydroxy-2-methyl-benzoic acid methyl ester；Isohaematommsaeure-methylester；3-Formyl-4,6-dihydroxy-2-methyl-benzoesaeure-methylester；4.6-Dihydroxy-2-methyl-isophthalaldehydsaeure-methylester；Methyl 3-formyl-4,6-dihydroxy-2-methylbenzoate；methyl 3-formyl-4,6-dihydroxy-2-methylbenzoate
• CAS: 64400-53-9
• 化学式: C₁₀H₁₀O₅
• 分子量: 210.186
• InChiKey: QGZOCMQCOZSUOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl isohaematommate 在 磺酰氯 作用下， 生成 3-chloro-2,4-dihydroxy-6-methyl-benzaldehyde
  参考文献：
  名称：

  Fujikawa; Tokuoka, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1950, vol. 70, p. 249

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-二甲氧基-6-甲基苯甲酸甲酯 在 三氯化硼 、 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 反应 5.5h， 生成 methyl isohaematommate
  参考文献：
  名称：

  Elix, John A.; Lajide, Labunmi, Australian Journal of Chemistry, 1984, vol. 37, # 26, p. 2153 - 2157

  摘要：

  DOI：

文献信息

• Fujikawa et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1956, vol. 76, p. 1326
  作者：Fujikawa et al.

  DOI：——

  日期：——
• A mechanism for restriction of the activation-zone propagation for a hemostasis system (A mathematical model)
  作者：I. F. Obraztsov、Yu. A. Barynin、M. A. Khanin

  DOI：10.1134/1.1342454

  日期：2000.12
• Chromium-Induced Glucose Uptake, Superoxide Anion Production, and Phagocytosis in Cultured Pulmonary Alveolar Macrophages of Weanling Pigs
  作者：Der-Nan Lee、Houng-Ta Yen、Tian-Fuh Shen、Bao-Ji Chen

  DOI：10.1385/bter:77:1:53

  日期：——

  The dose-dependent effects of chromium chloride(CrCl3) and chromium picolinate (CrPic) were evaluated for their glucose uptake, superoxide anion (O-2(-)) production, activity of glucose-6-phosphate dehydrogenase, and phagocytosis of incubated pulmonary alveolar macrophages in medium containing no or 5 x 10(-8)M insulin. Glucose uptake was found to increase in cells treated with 20 mug/L CrCl3. Incubation with 20 mug/L of CrPic enhanced glucose uptake and O-2(-) production in an insulin-dependent manner. However, the inclusion of CrPic to 100 mug/L in the medium absent of insulin also increased O-2(-) production. The activity of glucose-6-phosphate dehydrogenase was not affected by either the addition of Cr or insulin. The phagocytosis of Escherichia coli by macrophages was enhanced significantly (p < 0.05) in medium containing 10-100 g/L CrCl3 or 20-100 mug/L CrPic in the presence of insulin. These results suggest that the addition of 10-20 mug/L CrCl3 enhances directly the cellular activity of macrophages, whereas the effect of CrPic requires the cooperative action of insulin in enhancing their glucose uptake and phagocytosis.
• Elix, John A.; Lajide, Labunmi, Australian Journal of Chemistry, 1984, vol. 37, # 26, p. 2153 - 2157
  作者：Elix, John A.、Lajide, Labunmi

  DOI：——

  日期：——
• Fujikawa; Tokuoka, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1950, vol. 70, p. 249
  作者：Fujikawa、Tokuoka

  DOI：——

  日期：——