4,5-bis[4-[2-(4-fluorophenyl)ethynyl]phenyl]-2-phenyl-1H-imidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4,5-bis[4-[2-(4-fluorophenyl)ethynyl]phenyl]-2-phenyl-1H-imidazole
• 化学式: C₃₇H₂₂F₂N₂
• 分子量: 532.592
• InChiKey: ARJZTLSJHATUKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  41
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4,5-bis[4-[2-(4-fluorophenyl)ethynyl]phenyl]-2-phenyl-1H-imidazole 在 碘 作用下， 以 二甲基亚砜 为溶剂， 反应 22.0h， 以71%的产率得到1-(4-fluorophenyl)-2-[4-[4-[4-[2-(4-fluorophenyl)-2-oxoacetyl]phenyl]-2-phenyl-1H-imidazol-5-yl]phenyl]ethane-1,2-dione
  参考文献：
  名称：

  New activated bisfluoroaromatic compounds

  摘要：

  Bis(p-fluorophenylethynyl) derivatives were obtained by the reaction of bisbromoaromatic compounds with p-fluorophenylacetylene in the presence of a Pd catalyst. Subsequent oxidation of these products using an I-2-DMSO system led to new bis(p-fluorophenylglyoxalyl)ketones, alpha-diketones, and heterocyclic compounds.

  DOI：

  10.1007/bf02495212
• 作为产物：
  描述：

  4-氟苯乙炔 、 4,5-bis(4-bromophenyl)-2-phenyl-1H-imidazole 在 反式双(三苯基膦)二氯溴钯(II) copper(l) iodide 、 三苯基膦 作用下， 以 N,N-二甲基乙酰胺 、 三乙胺 为溶剂， 反应 10.0h， 以31%的产率得到4,5-bis[4-[2-(4-fluorophenyl)ethynyl]phenyl]-2-phenyl-1H-imidazole
  参考文献：
  名称：

  New activated bisfluoroaromatic compounds

  摘要：

  Bis(p-fluorophenylethynyl) derivatives were obtained by the reaction of bisbromoaromatic compounds with p-fluorophenylacetylene in the presence of a Pd catalyst. Subsequent oxidation of these products using an I-2-DMSO system led to new bis(p-fluorophenylglyoxalyl)ketones, alpha-diketones, and heterocyclic compounds.

  DOI：

  10.1007/bf02495212

文献信息

• New activated bisfluoroaromatic compounds
  作者：A. L. Rusanov、M. L. Keshtov、N. M. Belomoina、A. K. Mikitaev、G. B. Sarkisyan、S. V. Keshtova

  DOI：10.1007/bf02495212

  日期：1997.4

  Bis(p-fluorophenylethynyl) derivatives were obtained by the reaction of bisbromoaromatic compounds with p-fluorophenylacetylene in the presence of a Pd catalyst. Subsequent oxidation of these products using an I-2-DMSO system led to new bis(p-fluorophenylglyoxalyl)ketones, alpha-diketones, and heterocyclic compounds.