2-N-[4-[(6-chloro-2-methoxyacridin-9-yl)amino]phenyl]-6-N-cyclopentyl-4-N-phenyl-1,3,5-triazine-2,4,6-triamine | 1203488-03-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-N-[4-[(6-chloro-2-methoxyacridin-9-yl)amino]phenyl]-6-N-cyclopentyl-4-N-phenyl-1,3,5-triazine-2,4,6-triamine
• CAS: 1203488-03-2
• 化学式: C₃₄H₃₁ClN₈O
• 分子量: 603.126
• InChiKey: RRHXRXBKGCZJPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  109
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  6-chloro-N2-(4-((6-chloro-2-methoxyacridin-9-yl)amino)phenyl)-N4-phenyl-1,3,5-triazine-2,4-diamine 、 环戊胺 在 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 2-N-[4-[(6-chloro-2-methoxyacridin-9-yl)amino]phenyl]-6-N-cyclopentyl-4-N-phenyl-1,3,5-triazine-2,4,6-triamine
  参考文献：
  名称：

  Synthesis of 9-anilinoacridine triazines as new class of hybrid antimalarial agents

  摘要：

  There is challenge and urgency to synthesize cost-effective chemotherapeutic agents for treatment of malaria after the widespread development of resistance to CQ. In the present study, we synthesized a new series of hybrid 9-anilinoacridine triazines using the cheap chemicals 6,9-dichloro-2-methoxy acridine and cyanuric chloride. The series of new hybrid 9-anilinoacridine triazines were evaluated in vitro for their antimalarial activity against CQ-sensitive 3D7 strain of Plasmodium falciparum and their cytotoxicity were determined on VERO cell line. Of the evaluated compounds, two compounds 17 (IC50 = 4.21 nM) and 22 (IC50 = 4.27 nM) displayed two times higher potency than CQ (IC50 = 8.15 nM). Most of the compounds showed fairly high selectivity index. The compounds 13 and 29 displayed > 96.59% and 98.73% suppression, respectively, orally against N-67 strain of Plasmodium yoelii in swiss mice at dose 100 mg/kg for four days. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.010

文献信息

• Synthesis of 9-anilinoacridine triazines as new class of hybrid antimalarial agents
  作者：Ashok Kumar、Kumkum Srivastava、S. Raja Kumar、S.K. Puri、Prem M.S. Chauhan

  DOI：10.1016/j.bmcl.2009.10.010

  日期：2009.12

  There is challenge and urgency to synthesize cost-effective chemotherapeutic agents for treatment of malaria after the widespread development of resistance to CQ. In the present study, we synthesized a new series of hybrid 9-anilinoacridine triazines using the cheap chemicals 6,9-dichloro-2-methoxy acridine and cyanuric chloride. The series of new hybrid 9-anilinoacridine triazines were evaluated in vitro for their antimalarial activity against CQ-sensitive 3D7 strain of Plasmodium falciparum and their cytotoxicity were determined on VERO cell line. Of the evaluated compounds, two compounds 17 (IC50 = 4.21 nM) and 22 (IC50 = 4.27 nM) displayed two times higher potency than CQ (IC50 = 8.15 nM). Most of the compounds showed fairly high selectivity index. The compounds 13 and 29 displayed > 96.59% and 98.73% suppression, respectively, orally against N-67 strain of Plasmodium yoelii in swiss mice at dose 100 mg/kg for four days. (C) 2009 Elsevier Ltd. All rights reserved.