N-(2-{2-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethoxy}ethyl)-N-methylmethanesulfonamide | 437382-52-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(2-{2-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethoxy}ethyl)-N-methylmethanesulfonamide
• 英文别名: N-[2-[2-[4-amino-2-(2-methoxyethyl)imidazo[4,5-c]quinolin-1-yl]ethoxy]ethyl]-N-methylmethanesulfonamide
• CAS: 437382-52-0
• 化学式: C₁₉H₂₇N₅O₄S
• 分子量: 421.52
• InChiKey: ZDFCKYOGYRXJDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-(2-methoxyethyl)-1-{2-[2-(methylamino)ethoxy]ethyl}-1H-imidazo[4,5-c]quinolin-4-amine 、 甲基磺酰氯 在 碳酸氢钠 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 N-(2-{2-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethoxy}ethyl)-N-methylmethanesulfonamide
  参考文献：
  名称：

  Sulfonamido ether substituted imidazoquinolines

  摘要：

  含有醚和磺胺基或磺胺酰胺功能团在1位的咪唑喹啉和四氢咪唑喹啉化合物可作为免疫应答调节剂。该发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且在治疗包括病毒性疾病和肿瘤性疾病在内的各种疾病中具有用途。

  公开号：

  US06677347B2

文献信息

• SULFONAMIDO ETHER SUBSTITUTED IMIDAZOQUINOLINES
  申请人：Crooks Stephen L.

  公开号：US20080306252A1

  公开（公告）日：2008-12-11

  Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and sulfonamide or sulfamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

  在1位点含有醚和磺酰胺或磺酰胺官能团的咪唑喹啉和四氢咪唑喹啉化合物可用作免疫应答调节剂。本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且在治疗包括病毒性疾病和肿瘤性疾病在内的各种情况中非常有用。
• Compositions for stimulation of mammalian innate immune resistance to pathogens
  申请人：The Board of Regents, The University of Texas System

  公开号：US10722573B2

  公开（公告）日：2020-07-28

  Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a StIR composition to the individual.

  本发明的实施方案涉及治疗、抑制或减弱已感染或有感染风险的个体的微生物感染的方法，包括向该个体施用有效量的 StIR 组合物的步骤。
• COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS
  申请人：The Board of Regents of The University of Texas System

  公开号：EP2411521A1

  公开（公告）日：2012-02-01
• METHODS AND COMPOSITIONS FOR ADAPTIVE IMMUNE MODULATION
  申请人：THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

  公开号：US20190269773A1

  公开（公告）日：2019-09-05

  Embodiments are directed to methods and compositions for modulating an immune response. In certain aspects the immune response is a type I hypersensitivity response. In particular aspects the subject has allergic asthma or allergic rhinitis. Using a conventional experimental asthma mouse model (BALB/c), the inventors demonstrate that aerosol administration of TLR agonists, in particular a combination of TLR2/6 and TLR9 agonist (e.g., TLR9 oligonucleotide agonist/PAM2CSK4) along with an antigen (e.g., ovalbumin (OVA)) suppresses the immune response as exemplified by the production of antigen-specific IgE and decreases the number of airway eosinophils in bronchoalveolar lavage fluid (BAL) in response to intraperitoneal (IP) immunization with an antigen mixed with alum.
• US6677347B2
  申请人：——

  公开号：US6677347B2

  公开（公告）日：2004-01-13