[(2R,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-[3-[1-(anthracen-9-ylmethyl)triazol-4-yl]propanoylamino]oxan-2-yl]methyl acetate | 1456716-83-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子
• 英文名称: [(2R,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-[3-[1-(anthracen-9-ylmethyl)triazol-4-yl]propanoylamino]oxan-2-yl]methyl acetate
• CAS: 1456716-83-8
• 化学式: C₃₄H₃₆N₄O₁₀
• 分子量: 660.681
• InChiKey: UEPMDUJYBCUIGA-BRAMSPLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  48
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  174
• 氢给体数：
  1
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  [(2R,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-[3-[1-(anthracen-9-ylmethyl)triazol-4-yl]propanoylamino]oxan-2-yl]methyl acetate 在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Efficient synthesis of 1,4-disubstituted triazolyl N-carboxamides via a simple and convenient MCR using basic alumina as solid support

  摘要：

  A microwave assisted green protocol for the synthesis of 1,4-disubstituted triazolyl N-carboxamides was explored using basic alumina as solid support. The method allows domino Ullmann-type reaction, Click reaction and formation of ester or amide linkages in a single reaction vessel using Cu(phen)(PPh3)Br and CMPA as catalyst and basic alumina as solid support in high yield. The protocol did not require addition of any external ligands or base. The method was also found to be equally good for the synthesis of bis triazole adducts. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.08.014
• 作为产物：
  描述：

  9-溴甲基蒽 在 aluminum oxide 、 溴代(1,10-菲咯啉)(三苯基膦)铜(I) 、 叠氮基三甲基硅烷 作用下， 以 氯仿 为溶剂， 生成 [(2R,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-[3-[1-(anthracen-9-ylmethyl)triazol-4-yl]propanoylamino]oxan-2-yl]methyl acetate
  参考文献：
  名称：

  Efficient synthesis of 1,4-disubstituted triazolyl N-carboxamides via a simple and convenient MCR using basic alumina as solid support

  摘要：

  A microwave assisted green protocol for the synthesis of 1,4-disubstituted triazolyl N-carboxamides was explored using basic alumina as solid support. The method allows domino Ullmann-type reaction, Click reaction and formation of ester or amide linkages in a single reaction vessel using Cu(phen)(PPh3)Br and CMPA as catalyst and basic alumina as solid support in high yield. The protocol did not require addition of any external ligands or base. The method was also found to be equally good for the synthesis of bis triazole adducts. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.08.014