1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-2-(isopropylamino)ethanol | 1223578-14-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-2-(isopropylamino)ethanol
• 英文别名: WR308257；1-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-2-(propan-2-ylamino)ethanol
• CAS: 1223578-14-0
• 化学式: C₁₆H₁₆F₆N₂O
• 分子量: 366.306
• InChiKey: GHJPGPNNFIPPNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  2-[2,8-二(三氟甲基)-4-喹啉基]环氧乙烷 、 异丙胺 以 乙醇 为溶剂， 生成 1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-2-(isopropylamino)ethanol
  参考文献：
  名称：

  甲氟喹和非哌啶类似物对氨基酸外排和红细胞性恶性疟原虫生长的平行抑制：对抗疟药作用机理的暗示。

  摘要：

  尽管甲氧喹（MQ）在某些患者中引起令人不安的精神副作用，但由于其对所有疟原虫的活性，给药方便性以及对儿童和孕妇的相对安全性，已被用于疟疾的预防和治疗。然而，目前尚无关于MQ的抗疟疾作用机制的共识。MQ机制的两个主要假设是抑制血红素结晶和抑制宿主细胞血红蛋白内吞作用。在本报告中，我们显示MQ是一种有效且快速的氨基酸，可从完整的寄生红细胞中排出氨基酸，这是衡量宿主血红蛋白内吞和分解代谢体内速率的一种方法。为了进一步探讨MQ的作用机理，我们比较了MQ和18个非哌啶类似物对氨基酸外排和寄生虫生长的影响。在这些密切相关的化合物中，对于寄生虫生长和亮氨酸外排的50％抑制浓度（IC50）值，观察到了近4个对数单位的极佳相关性。这些数据和其他观察结果与以下假设相吻合：这些化合物的抗疟疾作用源自抑制血红蛋白内吞作用。

  DOI：

  10.1016/j.bmcl.2016.08.005

文献信息

• Compositions for the treatment of pancreatic cancer and uses thereof
  申请人：University of Florida Research Foundation, Incorporated

  公开号：US10835524B2

  公开（公告）日：2020-11-17

  The invention pertains to compositions comprising inhibitors of PI3K, AKT and/or mTOR, one or more 4-quinolinemethanols and a pharmaceutically acceptable excipient. These compositions can contain subtherapeutic amounts of each active ingredient (PI3K, AKT, mTOR, one or more 4-quinolinemethanols and various combinations thereof). The invention also provides a method of treating various forms of cancer, such as breast cancer, prostate cancer, multiple myeloma, hepatocyte carcinoma, brain cancer, lung cancer, non-small cell lung carcinoma, colorectal cancer, melanoma and/or pancreatic cancer.

  本发明涉及由 PI3K、AKT 和/或 mTOR 抑制剂、一种或多种 4-喹啉甲醇和药学上可接受的赋形剂组成的组合物。这些组合物可以包含亚治疗量的每种活性成分（PI3K、AKT、mTOR、一种或多种 4-喹啉甲醇及其各种组合）。本发明还提供了一种治疗各种形式癌症的方法，如乳腺癌、前列腺癌、多发性骨髓瘤、肝细胞癌、脑癌、肺癌、非小细胞肺癌、结直肠癌、黑色素瘤和/或胰腺癌。
• Structure–activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum
  作者：Erin Milner、William McCalmont、Jayendra Bhonsle、Diana Caridha、Dustin Carroll、Sean Gardner、Lucia Gerena、Montip Gettayacamin、Charlotte Lanteri、ThuLan Luong、Victor Melendez、Jay Moon、Norma Roncal、Jason Sousa、Anchalee Tungtaeng、Peter Wipf、Geoffrey Dow

  DOI：10.1016/j.bmcl.2010.01.001

  日期：2010.2

  Utilizing mefloquine as a scaffold, a next generation quinoline methanol (NGQM) library was constructed to identify early lead compounds that possess biological properties consistent with the target product pro. le for malaria chemoprophylaxis while reducing permeability across the blood-brain barrier. The library of 200 analogs resulted in compounds that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum. Herein we report selected chemotypes and the emerging structure activity relationship for this library of quinoline methanols. Published by Elsevier Ltd.
• COMPOSITIONS FOR THE TREATMENT OF CANCER AND USES THEREOF
  申请人：University of Florida Research Foundation Incorporated

  公开号：US20180177776A1

  公开（公告）日：2018-06-28

  The invention pertains to compositions comprising inhibitors of PI3K, AKT and/or mTOR, one or more 4-quinolinemethanols and a pharmaceutically acceptable excipient. These compositions can contain subtherapeutic amounts of each active ingredient (PI3K, AKT, mTOR, one or more 4-quinolinemethanols and various combinations thereof). The invention also provides a method of treating various forms of cancer, such as breast cancer, prostate cancer, multiple myeloma, hepatocyte carcinoma, brain cancer, lung cancer, non-small cell lung carcinoma, colorectal cancer, melanoma and/or pancreatic cancer.
• [EN] COMPOSITIONS FOR THE TREATMENT OF CANCER AND USES THEREOF<br/>[FR] COMPOSITIONS DESTINÉES AU TRAITEMENT DU CANCER, ET LEURS UTILISATIONS
  申请人：UNIV FLORIDA

  公开号：WO2016209688A1

  公开（公告）日：2016-12-29

  The invention pertains to compositions comprising inhibitors of PI3K, AKT and/or mTOR, one or more 4-quinolinemethanols and a pharmaceutically acceptable excipient. These compositions can contain subtherapeutic amounts of each active ingredient (PI3K, AKT, mTOR, one or more 4-quinolinemethanols and various combinations thereof). The invention also provides a method of treating various forms of cancer, such as breast cancer, prostate cancer, multiple myeloma, hepatocyte carcinoma, brain cancer, lung cancer, non- small cell lung carcinoma, colorectal cancer, melanoma and/or pancreatic cancer.
• Parallel inhibition of amino acid efflux and growth of erythrocytic Plasmodium falciparum by mefloquine and non-piperidine analogs: Implication for the mechanism of antimalarial action
  作者：Maryam Ghavami、Christie H. Dapper、Seema Dalal、Kristina Holzschneider、Michael Klemba、Paul R. Carlier

  DOI：10.1016/j.bmcl.2016.08.005

  日期：2016.10

  non-piperidine analogs on amino acid efflux and parasite growth. Among these closely related compounds, an excellent correlation over nearly 4 log units is seen for 50% inhibition concentration (IC50) values for parasite growth and leucine efflux. These data and other observations are consistent with the hypothesis that the antimalarial action of these compounds derives from inhibition of hemoglobin endocytosis

  尽管甲氧喹（MQ）在某些患者中引起令人不安的精神副作用，但由于其对所有疟原虫的活性，给药方便性以及对儿童和孕妇的相对安全性，已被用于疟疾的预防和治疗。然而，目前尚无关于MQ的抗疟疾作用机制的共识。MQ机制的两个主要假设是抑制血红素结晶和抑制宿主细胞血红蛋白内吞作用。在本报告中，我们显示MQ是一种有效且快速的氨基酸，可从完整的寄生红细胞中排出氨基酸，这是衡量宿主血红蛋白内吞和分解代谢体内速率的一种方法。为了进一步探讨MQ的作用机理，我们比较了MQ和18个非哌啶类似物对氨基酸外排和寄生虫生长的影响。在这些密切相关的化合物中，对于寄生虫生长和亮氨酸外排的50％抑制浓度（IC50）值，观察到了近4个对数单位的极佳相关性。这些数据和其他观察结果与以下假设相吻合：这些化合物的抗疟疾作用源自抑制血红蛋白内吞作用。