2-methyl-6-methylene-8,8-diethoxyoct-2-ene | 1222538-37-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methyl-6-methylene-8,8-diethoxyoct-2-ene
• 英文别名: 8,8-diethoxy-2-methyl-6-methylideneoct-2-ene
• CAS: 1222538-37-5
• 化学式: C₁₄H₂₆O₂
• 分子量: 226.359
• InChiKey: GNJXLLSSAMNFJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-methyl-1-[(1-methylene-3,3-diethoxypropyl)-4-methylpent-3-en-1-ylsulfonyl]benzene 在 乙醇 、 sodium 作用下， 以 四氢呋喃 、 乙醚 、 Petroleum ether 为溶剂， 生成 (5EZ)-2,6-dimethyl-8,8-diethoxy-2,5-octadiene 、 2-methyl-6-methylene-8,8-diethoxyoct-2-ene
  参考文献：
  名称：

  Preparation of 3-bromomethyl-3-butenal diethylacetal and its conversion into isoprenoid aldehydes derivatives

  摘要：

  The cyclopropanation of ethyl 3,3-diethoxypropionate with alkoxytitanacyclopropane reagents followed by the cleavage of the three-membered carbocycle in the formed cyclopropyl mesylate provided in a good yield 3-bromomethyl-3-butenal diethylacetal. The latter was brought into reactions of aldehyde allylation and cross-coupling with allyl halides in the intermediate stages at the generation of carbanionic intermediates. The conversion of compounds obtained into the corresponding beta, gamma- or alpha,beta-unsaturated aldehydes demonstrated the opportunity of applying 3-bromomethyl-3-butenal diethylacetal as a C-5-isoprenoid building block.

  DOI：

  10.1134/s1070428009110086