(2S,3R)-3-hydroxy-2-methyl-2-propylcyclopentan-1-one | 81969-86-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3R)-3-hydroxy-2-methyl-2-propylcyclopentan-1-one
• CAS: 81969-86-0
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: KAJKOFDGOSLJQC-APPZFPTMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲基-1,3-环戊二酮 在 platinum(IV) oxide sodium hydroxide 、 sodium tetrahydroborate 、 氢气 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 31.0h， 生成 (2S,3R)-3-hydroxy-2-methyl-2-propylcyclopentan-1-one
  参考文献：
  名称：

  Asymmetric microbial reduction of prochiral 2,2,-disubstituted cycloalkanediones

  摘要：

  DOI：

  10.1021/jo00391a009

文献信息

• Comparative reductive desymmetrization of 2,2-disubstituted-cycloalkane-1,3-diones
  作者：Jeremy M. Carr、Timothy S. Snowden

  DOI：10.1016/j.tet.2008.01.065

  日期：2008.3

  Reductive desymmetrization of 2-methyl-2-substituted-cycloalkane-1,3-diones can be effected using either NaBH(4) in DME or lithium tri-tert-butoxyaluminum hydride (LTBA) in THF at -60 degrees C. The former is a new approach that offers slightly greater diastereoselectivity in the reduction of 2,2-disubstituted-cyclopentane- 1,3-diones while LTBA is superior with 2,2-disubstituted-cyclohexane- 1,3-diones. Both conditions minimize subsequent reduction to diols thereby furnishing high yields of 1,3-ketols. Particularly rapid monoreductions are observed with 2-methyl-2-nitroethylcyclopentane-1,3-dione and 2-cyanoethyl-2-methylcyclopentane-1,3-dione when treated with NaBH(4) in DME at -60 degrees C. As expected, diastereoselectivity varies considerably with the substitution at C-2. (C) 2008 Elsevier Ltd. All rights reserved.
• Chiral cyclopentanoid synthetic intermediates via asymmetric microbial reduction of prochiral 2,2-disubstituted cyclopentanediones
  作者：Dee W. Brooks、Paul G. Grothaus、William L. Irwin

  DOI：10.1021/jo00135a039

  日期：1982.7